Wrist Cartilage - High Resolution in Vivo MR T2 Mapping- a Feasibility Study
NCT ID: NCT00669201
Last Updated: 2008-04-30
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
70 participants
OBSERVATIONAL
2007-12-31
Brief Summary
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Study protocol: Phase 1. 10 healthy volunteers, Phase 2. 10 volunteers with osteoarthritis of the wrist, Phase 3. 50 patients for studies for routine MR of the wrist.
MRI protocol: 3 T unit((Signa EXITE HDx),T1, T2 and T2 mapping sequences on axial and coronal orientation.
Detailed Description
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Conditions
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Keywords
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Study Design
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COHORT
CROSS_SECTIONAL
Study Groups
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1
healthy young volunteers Inclusion: age 18-40, Exclusion: wrist trauma/surgery
No interventions assigned to this group
2
patients with know osteoarthritis wrist changes according to pre-existing x-rays No age limits
exclusion: previous wrist surgery
No interventions assigned to this group
3
Mixed group of 50 patients that perform routine MRI of the wrist for various indications
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Phase 2: No age limit, known OA on pre-existing X-rays
* Phase 3: No age limit, routine MRI of the wrist
Exclusion Criteria
* All phases: any contraindication for MR: eg metals, claustrophobia, etc.
18 Years
80 Years
ALL
Yes
Sponsors
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Sheba Medical Center
OTHER_GOV
Responsible Party
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Sheba Medical Center
Principal Investigators
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Iris Eshed, MD
Role: PRINCIPAL_INVESTIGATOR
Sheba Medical Center
Locations
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Sheba Medical Center , Diagnostic Imaging Dept
Tel Litwinsky, Tel Hashomer, Israel
Sheba Medical Center, Diagnostic Imaging Dept
Tel Litwinsky, Tel Hashomer, Israel
Countries
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Facility Contacts
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Iris Eshed, MD
Role: primary
References
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Glaser C. New techniques for cartilage imaging: T2 relaxation time and diffusion-weighted MR imaging. Radiol Clin North Am. 2005 Jul;43(4):641-53, vii. doi: 10.1016/j.rcl.2005.02.007.
Recht MP, Goodwin DW, Winalski CS, White LM. MRI of articular cartilage: revisiting current status and future directions. AJR Am J Roentgenol. 2005 Oct;185(4):899-914. doi: 10.2214/AJR.05.0099.
Mosher TJ, Dardzinski BJ, Smith MB. Human articular cartilage: influence of aging and early symptomatic degeneration on the spatial variation of T2--preliminary findings at 3 T. Radiology. 2000 Jan;214(1):259-66. doi: 10.1148/radiology.214.1.r00ja15259.
Other Identifiers
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SHEBA-08-4912-IE-CTIL
Identifier Type: -
Identifier Source: org_study_id