MR Imaging of Knee Osteoarthritis and Acute Knee Injuries
NCT ID: NCT00504114
Last Updated: 2013-12-12
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
139 participants
OBSERVATIONAL
2006-08-31
2013-07-31
Brief Summary
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Detailed Description
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All OA and Anterior cruciate ligament (ACL) subjects will undergo MR imaging of the knee joint at 3 Tesla at baseline,, and three annual follow up time points. Regions of interest will include the total tibial and femoral cartilage, and sub-division such as the medial and lateral compartments of the tibial and femoral cartilage to account for localized disease activity and progression.
Bone marrow edema size, MR spectroscopy based marrow fat/water content, and trabecular bone microarchitecture underlying the edema will be measured in the OA and ACL groups to determine whether there is any distinction between these measures in OA and in traumatic ACL injury, cross-sectionally and longitudinally, and their relation to cartilage loss and OA progression.
Conditions
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Keywords
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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1
Healthy volunteers without knee pain.
No interventions assigned to this group
2
Patients with mild arthritic symptoms and radiographic changes (Kellgren Lawrence score of 1, 2)
No interventions assigned to this group
3
Patients with severe pain and functional limitations associated with knee arthritis (Kellgren Lawrence score of 3, 4).
Total Knee Replacement
4
Patients with acute anterior cruciate ligament (ACL) injuries with associated osseous contusion.
ACL Reconstruction Surgery
5
Patients with posttraumatic knee injury or degenerative condition and will have cartilage resurfacing procedures.
Cartilage Resurfacing Surgery
Interventions
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ACL Reconstruction Surgery
Cartilage Resurfacing Surgery
Total Knee Replacement
Eligibility Criteria
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Inclusion Criteria
* Patients with mild arthritic symptoms and Kellgren Lawrence score of 2
* Patients with severe arthritic symptoms and Kellgren Lawrence score of 3, or 4
* Patients with acute ACL injury with associated bone contusion and bone edema
* Patients with posttraumatic knee injury or degenerative condition and will have cartilage resurfacing procedures
* Patient is willing to participate in the proposed study as evidenced by providing written informed consent.
Exclusion Criteria
* Conditions other than OA which limit lower extremity function and mobility and/or would confound the evaluation of function (e.g., clinically significant spinal disc degeneration, painful or dysfunctional feet, peripheral vascular disease, lumbar radiculopathy or a stroke.)
* Patients with metallic fragments in the eyes, vascular clips, pacemakers, and other contraindications to MRI
18 Years
ALL
Yes
Sponsors
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National Institutes of Health (NIH)
NIH
University of California, San Francisco
OTHER
Responsible Party
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Principal Investigators
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Sharmila Majumdar, Ph.D.
Role: PRINCIPAL_INVESTIGATOR
University of California, San Francisco
Locations
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University of California, San Francisco; MR Surbeck Laboratory of Advanced Imaging
San Francisco, California, United States
Countries
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Other Identifiers
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