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Obesity and the Initiation of Knee Osteoarthritis

NCT ID: NCT00856739

Last Updated: 2014-12-19

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

177 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-03-31

Study Completion Date

2012-03-31

Brief Summary

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Healthy adults aged 20-60 of varying weights will participate in this minimally invasive study. There is one 4-hour appointment for which subjects are paid $120. The tests involve: 1 tube blood draw, 1 gait test (motion capture) and 1 MR of both knees.

Detailed Description

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The tests will be done at the VA and Stanford and are not dangerous or painful. They are designed to help us learn more about the relationship of excess weight on cartilage degradation by testing a biomarker in blood. Gait testing involves walking in a lab that is about 20 meters long about 20 times. MR involves lying in a tube for less than 1 hour.

Conditions

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Obesity

Keywords

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obesity arthritis

Study Design

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Observational Model Type

ECOLOGIC_OR_COMMUNITY

Study Groups

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Group 1

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Healthy Adults aged 20-60 who have no history of LE surgery
* Healthy adults able to walk 30 minutes
* Healthy adults able to have MR

Exclusion Criteria

* Adults who have had LE surgery
* Adults cannot walk 30 minutes
* Adults who cannot tolerate MR
* Adults with osteoarthritis
Minimum Eligible Age

20 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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US Department of Veterans Affairs

FED

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Thomas P. Andriacchi, PhD

Role: PRINCIPAL_INVESTIGATOR

VA Palo Alto Health Care System

Locations

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VA Palo Alto Health Care System

Palo Alto, California, United States

Site Status

Countries

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United States

References

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Blazek K, Favre J, Asay J, Erhart-Hledik J, Andriacchi T. Age and obesity alter the relationship between femoral articular cartilage thickness and ambulatory loads in individuals without osteoarthritis. J Orthop Res. 2014 Mar;32(3):394-402. doi: 10.1002/jor.22530. Epub 2013 Nov 26.

Reference Type RESULT
PMID: 24281940 (View on PubMed)

Blazek K, Asay JL, Erhart-Hledik J, Andriacchi T. Adduction moment increases with age in healthy obese individuals. J Orthop Res. 2013 Sep;31(9):1414-22. doi: 10.1002/jor.22390. Epub 2013 Jun 4.

Reference Type RESULT
PMID: 23737249 (View on PubMed)

Other Identifiers

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7924

Identifier Type: OTHER

Identifier Source: secondary_id

A6650-R

Identifier Type: -

Identifier Source: org_study_id