the New Biomarker of the Knee Osteoarthritis Knee Osteoarthritis Occurrence and Progression

NCT ID: NCT03015688

Last Updated: 2017-01-10

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 460 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2012-06-30
• Study Completion Date: 2015-06-30

Brief Summary

It was previously proved an association of TGF-β1 and PDGF-BB with the pathogenesis of osteoarthritis (OA) by experiments of OA animal models. In this study, we aimed to determine whether serum concentrations of TGF-β1, PDGF-BB and CTX-1 were related to the knee OA. knee OA cases were collected from the first affiliated hospital of Shihezi university and healthy controls were recruited from the community. The severity of knee OA was defined as kellgren-lawrence (K-L) classification criteria.Serum levels of chemical biomarkers were compared between knee OA cases and controls or among K-L grade 2 to grade 4 groups. The serum concentrations of the TGF-β1, PDGF-BB and CTX-1 were determined by ELISA .

Conditions

Knee Osteoarthritis

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

knee OA

OA diagnosis was on the basis of the diagnosis and treatment guideline of the American Academy of Orthopedic Surgeons Participants who met the following criteria were excluded：the knee OA concomitant with hip OA, suppurative and rheumatoid arthritis, gout patients, patients who underwent knee arthroscopy surgery within 6 months, bilateral or unilateral knee replacements, the knee joint trauma patients, histories of glucocorticoid and/or sterol hormones.

x-ray images

Intervention Type: RADIATION

Control

"no often have pain, aching or stiffness in your Left/right knee during last month","no Left/right knee trauma history","no histories of glucocorticoid and/or sterol hormones" normal knee X-ray images,

x-ray images

Intervention Type: RADIATION

Interventions

x-ray images

Intervention Type: RADIATION

Eligibility Criteria

Inclusion Criteria

• OA diagnosis was on the basis of the diagnosis and treatment guideline of the American Academy of Orthopedic Surgeons

Exclusion Criteria

Participants who met the following criteria were excluded：

• the knee OA concomitant with hip OA,
• suppurative and rheumatoid arthritis,
• gout patients,
• patients who underwent knee arthroscopy surgery within 6 months,
• bilateral or unilateral knee replacements,
• the knee joint trauma patients,
• histories of glucocorticoid and/or sterol hormones.

• Minimum Eligible Age: 38 Years
• Maximum Eligible Age: 78 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Shihezi University

OTHER

Sponsor Role: lead

Responsible Party

Jianwei He

Principal investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Other Identifiers

2012-06-01

Identifier Type: -

Identifier Source: org_study_id