Synovitis in Patients With Osteoarthritis

NCT ID: NCT05617573

Last Updated: 2023-01-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

272 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-11-01

Study Completion Date

2022-12-31

Brief Summary

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To study synovial membrane (SM) inflammation in suprapatellar fossa in advanced knee osteoarthritis (OA), and to correlate the pathological features with clinical findings.

Detailed Description

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Conditions

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Osteoarthritis, Knee

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients undergone TKA due to advanced knee osteoarthritis

Total knee arthroplasty due to advanced osteoarthritis.

Intervention Type PROCEDURE

Postoperative usage of intravenous methylprednisolone

Interventions

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Total knee arthroplasty due to advanced osteoarthritis.

Postoperative usage of intravenous methylprednisolone

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* patients undergoing elective, unilateral, primary TKA for advanced osteoarthritis.

Exclusion Criteria

\- revisions, bilateral procedures, alcohol or medical abuse, administration of any glucocorticoids during the 3 months prior to surgery, and/or a history of serious cardiac or cerebrovascular problems, severe liver or kidney failure, and/or connective tissue disease including rheumatoid arthritis, ankylosing spondylitis, and systemic lupus erythematosus.
Minimum Eligible Age

55 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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The Affiliated Hospital of Qingdao University

OTHER

Sponsor Role lead

Responsible Party

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Xiang Shuai, MD

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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The affiliated hospital of Qingdao University

Qingdao, Shandong, China

Site Status

Countries

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China

Other Identifiers

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OASynoviumAHQD

Identifier Type: -

Identifier Source: org_study_id

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