Characteristics of Marrow Fatty Cells in the Ageing of Bone and Joints, Osteoarthritis and Osteoporosis

NCT ID: NCT03678831

Last Updated: 2025-12-05

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 45 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2020-06-30
• Study Completion Date: 2024-03-11

Brief Summary

Obesity and other associated complications promote the development and the progression of osteoarthritis. The subcutaneous and abdominal fat release several factors that alter bone and the cartilage. The role of the marrow fat in close connection with bone has not been defined yet, whereas cellular and animal models indicate that this fat depot modifies bone and cartilage.

The aim of the study is to define if the marrow fat produces more joint-altering factors by comparison with subcutaneous fat. This fat depot can be characterized from removed pieces during the prosthetic surgery of the knee. Measuring before surgery the body weight, waist and hip circumferences, blood pressure, glucose, insulin and lipids in blood will also allow to determine if obesity and/or type 2 diabetes make this fat more dangerous for the joint. Such research will allow the elaboration of new therapeutic strategies in osteoarthritis.

Conditions

Osteoarthritis, Knee; Prosthesis User

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Study Groups

Arthritic patients with knee prosthetic replace

Arthritic post-menopausal patients with knee prosthetic replacement Each patient is her own control since the two cell types are compared within the same patient The main criteria is based on a comparison of two cell types from the same patient. The secondary criteria are based on a comparison of cell types according to a grouping of patients according to different metabolic parameters.

tissue

Intervention Type: PROCEDURE

Adipocyte isolation from distal femoral epiphysis and subcutaneous adipose tissue at the surgery site; classical piece removal during prosthetic replacement of the knee

Interventions

tissue

Adipocyte isolation from distal femoral epiphysis and subcutaneous adipose tissue at the surgery site; classical piece removal during prosthetic replacement of the knee

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

• Post-menopausal woman
• with a symptomatic knee osteoarthritis requiring prosthesis
• able to handle general anaesthesia
• having given her consent
• able to understand the constraints associated with the study
• with health insurance
• able to understand the French language

Exclusion Criteria

• with refusal to participate to the study
• more than 85-year-old
• with bone pathologies other than osteoarthritis or osteoporosis
• with active infection
• with evolving cancer
• with haematopoietic pathologies such as haemoglobin pathologies
• with thyroid pathologies
• with type 1 diabetes
• with anti-osteoporotic treatments (bisphosphonates, strontium ranelate, teriparatide, denosumab) except calcium and vitamin D supplementation or hormone replacement.
• with replacement of prosthesis
• with previous surgery at the surgery site

--with a current participation to another study

• with guardianship
• with deprived liberty

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 85 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: No

Sponsors

MSDAVENIR Foundation

UNKNOWN

Sponsor Role: collaborator

University Hospital, Lille

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Gilles Pasquier, MD

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Lille

Locations

Hopital Roger Salengro, CHU Lille

Lille, , France

Countries

France

Other Identifiers

2018-A00660-55

Identifier Type: OTHER

Identifier Source: secondary_id

2017_59

Identifier Type: -

Identifier Source: org_study_id