Effect of High Intensity Interval Training in Patients With Multiple Sclerosis

NCT ID: NCT05954195

Last Updated: 2023-07-20

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 86 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-07-20
• Study Completion Date: 2023-12-18

Brief Summary

In this study, we are aiming to systematically review the literature on the effect of HIIT on MS patients as improving physical performance, cognitive function, aerobic fitness and muscle strength. This could help guide the development of standardized clinical guidelines and direct clinical decision making by the physical therapists whether to implement this type of exercises or not.

Detailed Description

Multiple sclerosis patients have considerably negative effects on the community and the national and international economy. Chronic symptoms of MS such as fatigue, cognitive impairments, emotional burden and diminished physical functioning considerably affect the daily lives of people with MS and may interfere with social and quality of life factors as friendships, family relationships and occupational status. HIIT has induced significant improvements in physiological conditioning in healthy and clinical populations, and might be appropriate for persons with MS. Recently, several RCTs have been published evaluating the effect of HIIT on MS patients. Consequently, this study will systematically review all these recent literature to direct the physiotherapists whether to implement this type of exercises or not.

Conditions

Multiple Sclerosis

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: OTHER
• Blinding Strategy: QUADRUPLE

Study Groups

HIIT group

The group who received high intensity interval training

Group Type: ACTIVE_COMPARATOR

high intensity interval training

Intervention Type: OTHER

high intensity interval training through ergometer, with whole treatment session between 20 - 30 minutes divided into 3 parts, the 1st is warming up (40% of HRmax intensity for 2/3/5 minutes then the active training part (intervals of 85-90% of HRmax for 1 minute then rest period of 1 minute of 40 % of HRmax and so on for nearly 20 minutes ) then the last part is cooling down (30 % of HRmax for 3/5 minutes).

control/comparator group

control group that might be placebo group, standard care group or no intervention group

Group Type: PLACEBO_COMPARATOR

high intensity interval training

Intervention Type: OTHER

high intensity interval training through ergometer, with whole treatment session between 20 - 30 minutes divided into 3 parts, the 1st is warming up (40% of HRmax intensity for 2/3/5 minutes then the active training part (intervals of 85-90% of HRmax for 1 minute then rest period of 1 minute of 40 % of HRmax and so on for nearly 20 minutes ) then the last part is cooling down (30 % of HRmax for 3/5 minutes).

Interventions

high intensity interval training

high intensity interval training through ergometer, with whole treatment session between 20 - 30 minutes divided into 3 parts, the 1st is warming up (40% of HRmax intensity for 2/3/5 minutes then the active training part (intervals of 85-90% of HRmax for 1 minute then rest period of 1 minute of 40 % of HRmax and so on for nearly 20 minutes ) then the last part is cooling down (30 % of HRmax for 3/5 minutes).

Intervention Type: OTHER

Other Intervention Names

progressive aerobic training; sprinting interval exercise

Eligibility Criteria

Inclusion Criteria

• Studies: English full texts of RCTs only, Participants: multiple sclerosis patients with age from (20-50) years old irrespectively of sex, subtype of MS, race, diagnostic criteria, community or onset of the disease, Intervention: HIIT, any comparator.

Exclusion Criteria

• Studies other than English full text RCTs, non adults younger than 20 years and older than 50 years, populations other than multiple sclerosis.

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 50 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Cairo University

OTHER

Sponsor Role: lead

Responsible Party

Fatma Khaled Mohamed Abdelaziz

Fatma Khaled Mohamed Abdelaziz

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Abeer Abobakr Dr Alwishy, Professor

Role: STUDY_CHAIR

Physical therapy for neuromuscular disorders and its surgeries, Cairo university

Neveen Mohy-Eldin shalaby, professor

Role: STUDY_CHAIR

Faculty of medicine, Alqasr elainy, Cairo university

Hossam M. Elsaid, lecturer

Role: STUDY_CHAIR

Faculty of physical therapy of neuromuscloskeletal disorders and its surgeries, Cairo universities

Locations

Azzarqa

Damietta, , Egypt

Site Status: RECRUITING

Countries

Egypt

Central Contacts

Fatma Khaled M. Abdelaziz, master

Role: CONTACT

fabdelaziz@horus.edu.eg

+2001006196295

Hossam M. Elsaid, lecturer

Role: CONTACT

Facility Contacts

Fatma Khaled M. Abdelaziz, Master

Role: primary

fabdelaziz@horus.edu.eg

+2001006196295

References

Zimmer P, Bloch W, Schenk A, Oberste M, Riedel S, Kool J, Langdon D, Dalgas U, Kesselring J, Bansi J. High-intensity interval exercise improves cognitive performance and reduces matrix metalloproteinases-2 serum levels in persons with multiple sclerosis: A randomized controlled trial. Mult Scler. 2018 Oct;24(12):1635-1644. doi: 10.1177/1352458517728342. Epub 2017 Aug 21.

Reference Type: RESULT

PMID: 28825348 (View on PubMed)

Langeskov-Christensen M, Grondahl Hvid L, Nygaard MKE, Ringgaard S, Jensen HB, Nielsen HH, Petersen T, Stenager E, Eskildsen SF, Dalgas U. Efficacy of High-Intensity Aerobic Exercise on Brain MRI Measures in Multiple Sclerosis. Neurology. 2021 Jan 12;96(2):e203-e213. doi: 10.1212/WNL.0000000000011241. Epub 2020 Dec 1.

Reference Type: RESULT

PMID: 33262230 (View on PubMed)

Spaas J, Goulding RP, Keytsman C, Fonteyn L, van Horssen J, Jaspers RT, Eijnde BO, Wust RCI. Altered muscle oxidative phenotype impairs exercise tolerance but does not improve after exercise training in multiple sclerosis. J Cachexia Sarcopenia Muscle. 2022 Oct;13(5):2537-2550. doi: 10.1002/jcsm.13050. Epub 2022 Aug 4.

Reference Type: RESULT

PMID: 35929063 (View on PubMed)

Other Identifiers

HIIT in MS patients

Identifier Type: -

Identifier Source: org_study_id