The Effect of High Intensity Interval Training on Cardiovascular Fitness in People With Progressive Multiple Sclerosis.
NCT ID: NCT02950454
Last Updated: 2017-10-25
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
12 participants
INTERVENTIONAL
2017-01-31
2017-09-30
Brief Summary
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Detailed Description
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The training program will entail 6x1.5 minute intervals working at 80-95% heart rate max on a cycle ergometer. Each interval will be interspersed with 1.5 minutes of working rest at a light resistance of the participant's choosing.
The continuous moderate intensity exercise program will entail 20 minutes on a cycle ergometer working at 60-70% heart rate max.
Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Intervention
8 weeks of twice weekly high intensity interval training. Session protocol: 2 minute warm up at nominal resistance on cycle ergometer, 6 six intervals of 80-95% heart rate max interspersed with 6 intervals of 1.5 minute working rest. Then 3 minutes cool down.
High intensity interval training
1.5 min intervals at 80-95% heart rate max on cycle ergometer 1.5 min intervals at nominal resistance on cycle ergometer
control
8 weeks of twice weekly continuous moderate intensity exercise. Session protocol: 2 minutes warm up at nominal resistance on cycle ergometer, 20 minutes at 60-70% heart rate max. Then 3 minutes cool down.
Continuous moderate exercise
20 min at 60-70% heart rate max on cycle ergometer
Interventions
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High intensity interval training
1.5 min intervals at 80-95% heart rate max on cycle ergometer 1.5 min intervals at nominal resistance on cycle ergometer
Continuous moderate exercise
20 min at 60-70% heart rate max on cycle ergometer
Eligibility Criteria
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Inclusion Criteria
* Aged 18 years or older
* Known to members of staff of the MS service NHS Ayrshire \& Arran
* Ability to attend Douglas Grant Rehabilitation centre twice a week for eight weeks
* EDSS 4-6.0
* Able to cycle on ergometer
Exclusion Criteria
* A respiratory condition that would be exacerbated by high intensity exercise including but not limited to: chronic obstructive pulmonary disorder, uncontrolled or poorly controlled asthma.
* Uncontrolled high pressure at screening (\>190/100 mmHg)
* Cognitive impairment affecting ability to understand instructions as noted in patient's notes.
* Currently engaging in another research trial for their MS or that may affect their physiological or cardiovascular outcomes
* Weighing more than 110 kg (weight limit of ergometer)
* Any pathology or medical intervention that would preclude high intensity exercise, maximal exertion testing or could attenuate the cardiovascular effect of exercise including but not limited to: unstable angina; diabetes; peripheral vascular disease or intermittent claudication; having a pace maker or medicine pump; surgical clips; having another neurological condition other than MS; and pregnancy. To be established from patient's notes and at screening session.
* A serious cardiovascular event in the past year including but not limited to: transient ischaemic attack, cerebrovascular event and myocardial infarction.
* Taking any of the following medication: beta blockers; vasodilators; ACE inhibitors; diuretics or any other medication that could cause exercise induced hypotension; hypoglycaemic insulin; metformin or other oral insulin medicine.
18 Years
ALL
Yes
Sponsors
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NHS Ayrshire and Arran
OTHER
AKM
OTHER
University of Glasgow
OTHER
Responsible Party
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Evan Campbell
PhD Student
Locations
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The University of Glasgow
Glasgow, , United Kingdom
Countries
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Other Identifiers
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1.0
Identifier Type: -
Identifier Source: org_study_id