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Multiple Sclerosis and Heavy Progressive Resistance Training

NCT ID: NCT00381576

Last Updated: 2008-08-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

36 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-11-30

Study Completion Date

2008-06-30

Brief Summary

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The purpose of the present investigation is to determine whether MS patients can tolerate and benefit from heavy progressive resistance training. A second purpose is to determine both neural and muscle morphological adaptations to heavy progressive resistance training.

Detailed Description

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Multiple sclerosis (MS) patients are characterized by reduced muscle strength and functional capacity. For MS patients, improvements in muscle strength and thereby functional capacity, would have the potential to make both the daily living easier and to extend the time living independently. Attempts to improve muscle strength and function include the application of physical training, although the general advice to MS patients for many years has been to avoid participation in physical training. It has now been demonstrated that endurance training at low to moderate intensity is well tolerated by MS patients, but it only induces modest improvements in both muscle strength and functional capacity. Heavy progressive resistance training (HPRT) has proven to be the most effective means to improve muscle strength and functional capacity during daily activities in healthy older people. However, the effects of HPRT have not been investigated in randomised control trials in MS patients.

Conditions

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Multiple Sclerosis

Keywords

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Resistance training Strength training Training adaptations CNS

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Blinding Strategy

SINGLE

Investigators

Study Groups

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A

12 weeks of resistance training

Group Type EXPERIMENTAL

Resistance training

Intervention Type BEHAVIORAL

Intervention group: 12 weeks of resistance training for the lower extremity. Control group: No intervention - 12 weeks of normal daily living

Interventions

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Resistance training

Intervention group: 12 weeks of resistance training for the lower extremity. Control group: No intervention - 12 weeks of normal daily living

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Clinical diagnosis of Relapsing Remitting Multiple Sclerosis according to the McDonald criteria
* Expanded Disability Status Scale Score between 3,0-5,5
* Be able to walk at least 100m
* Be able to train twice a week at the University

Exclusion Criteria

* Alcohol abuse, Alzheimer's and pacemaker
* Comorbidities like cardiovascular-, respiratory-, orthopaedic or metabolic diseases
* Having had an attack in a period of 8 weeks prior to the start of the intervention period
* Having an attack during the intervention period
* Pregnancy
* Systematic resistance training in a period of 3 months prior to the start of the intervention period.
* Training adherence of less than 85%.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sonderborg Hospital

OTHER_GOV

Sponsor Role collaborator

The Danish Multiple Sclerosis Society

UNKNOWN

Sponsor Role collaborator

University of Aarhus

OTHER

Sponsor Role lead

Responsible Party

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Aarhus University

Principal Investigators

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Ulrik Dalgas, Ph.d. Stud.

Role: PRINCIPAL_INVESTIGATOR

Department of Sports Science, University of Aarhus

Thorsten Ingemann-Hansen, Professor

Role: STUDY_CHAIR

Department of Sports Science, University of Aarhus

Egon Stenager, MD

Role: STUDY_CHAIR

MS clinic, Department of Neurology, Sonderborg Hospital

Locations

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MS Clinic, Department of Neurology, Aarhus University Hospital

Aarhus, , Denmark

Site Status

Department of Sports Science, University of Aarhus

Aarhus, , Denmark

Site Status

Countries

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Denmark

References

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Dalgas U, Stenager E, Lund C, Rasmussen C, Petersen T, Sorensen H, Ingemann-Hansen T, Overgaard K. Neural drive increases following resistance training in patients with multiple sclerosis. J Neurol. 2013 Jul;260(7):1822-32. doi: 10.1007/s00415-013-6884-4. Epub 2013 Mar 13.

Reference Type DERIVED
PMID: 23483214 (View on PubMed)

Dalgas U, Severinsen K, Overgaard K. Relations between 6 minute walking distance and 10 meter walking speed in patients with multiple sclerosis and stroke. Arch Phys Med Rehabil. 2012 Jul;93(7):1167-72. doi: 10.1016/j.apmr.2012.02.026. Epub 2012 Mar 12.

Reference Type DERIVED
PMID: 22421626 (View on PubMed)

Other Identifiers

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300976

Identifier Type: -

Identifier Source: org_study_id