Evaluation of Vitamin A and E Deficiency With Severity of SARS-COV-2 Disease: A Case-Control Study
NCT ID: NCT05946499
Last Updated: 2023-08-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
90 participants
OBSERVATIONAL
2021-09-01
2022-05-30
Brief Summary
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Vitamin A is of special interest in the field of infectious diseases, especially for pulmonary infections. It is crucial for the development of normal lung tissue and tissue repair after injury due to infection. Therefore, it may play a role in recovery after severe COVID-19 pneumonia. Vitamin A has immune regulatory functions and positively affects both the innate and adaptive immune cell response.
The anti-oxidant Vitamin E, and trace element selenium, are major components of anti-oxidant defense. Epidemiological studies demonstrate that deficiencies in, either of these nutrients, alters immune responses and viral pathogenicity.
Data concerning vitamin A and E plasma levels in COVID-19 patients are lacking. Therefore, this study aims at characterizing vitamin A and E plasma levels in COVID-19 and analyzing the association of plasma levels with disease severity and outcome.
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Group A
30 ICU-admitted SARS-CoV-2- infected individuals with ARDS or in need of oxygen supplementation
No interventions assigned to this group
Group B
30 ward-admitted SARS-CoV-2-infected individuals not suffering from ARDS and not in need of oxygen supplementation
No interventions assigned to this group
Group C
30 sex and age-matched normal individuals
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Patients aging 18 to 75 years
Exclusion Criteria
18 Years
75 Years
ALL
No
Sponsors
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Cairo University
OTHER
Responsible Party
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Balsam Sherif Fahmy
Lecturer
Locations
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balsam Sherif Fahmy
Cairo, None Selected, Egypt
Countries
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Other Identifiers
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Vitamin A and E in COVID-19
Identifier Type: -
Identifier Source: org_study_id
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