The Effect of Vitamin D Supplementation on COVID-19 Recovery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

130 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-04-22

Study Completion Date

2020-10-31

Brief Summary

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The COVID-19 caused by SARS-CoV-2 has transmitted quickly as a global public health emergency. The median duration for Sars-CoV-2 carrying in COVID-19 patients was 20 days (IQR 16-28) What is the role of vitamin D supplementation on the recovery time of asymptomatic and pauci-symptomatic COVID-19 subjects? the intervention group will have vitamin D supplementation (200,000 IU / 1 ml of Cholecalciferol (1 ml) Oral form). Control group will have a placebo treatment (physiological saline).

the negative RT-PCR date will be compared in the two groups

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Detailed Description

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Introduction In 2020 The world is incurring coronavirus pandemic. The epidemic of the new coronavirus started in Wuhan, China, in late 2019, originally called 2019-nCoV and then COVID-19 by the World Health Organization in February 2020.

COVID-19 presented a heavy health systems burden having caused more than 170,000 deaths worldwide as of April 20, 2020. However, the treatment protocols for this infection remain controversial. It is the subject of several ongoing studies.

The use of vitamin D as a strategy to reduce the frequency and severity of respiratory infections and in particular COVID-19 must be seriously considered.

Several studies have studied the role of vitamin D in reducing the risk of viral infections. Indeed, vitamin D supplementation could be a useful measure in improving the immune response of subjects affected by the new coronavirus. This, taking into account the high prevalence of vitamin D deficiency in our country.

The beneficial effects of vitamin D on protective immunity is partly due to innate immune system action. It reduces the cytokine storm induced by the innate immune system, by decreasing the expression of pro-inflammatory cytokines and increasing that of anti-inflammatory cytokines. Vitamin D played a major role in the modulation of adaptive immunity. However, evidence on the effectiveness of vitamin D in improving the immune response of confirmed COVID-19 remains lacking.

The prolonged duration of the disease may increase the likelihood of transmission. Indeed, the R0 depends on three factors including the contact rate between individuals in the population, the probability of transmission of the infection during contact and the duration of infectiousness. The COVID-19 caused by SARS-CoV-2 has transmitted quickly as a global public health emergency. The median duration for Sars-CoV-2 carrying in COVID-19 patients was 20 days (IQR 16-28)(9).

1. Research question:

What is the role of vitamin D supplementation on the recovery time of asymptomatic and pauci-symptomatic COVID-19 subjects?
2. Objectives of the study:

To assess the effect of vitamin D supplementation on the duration of carriage of the COVID-19 virus in patients with SARS Cov2 with a positive control RT-PCR on day 14 of the date of confirmation of the disease.
3. Type of study:

This is a randomized clinical trial without the patient's knowledge in subjects diagnosed with COVID-19.

B. Method:

1. Study setting: this study will be carried out in the governorate of Monastir in the collective isolation center
2. Eligibility criteria: patients with SARS Cov2 and having a positive RT-PCR at control in

* 14 days from confirmation of infection for asymptomatic subjects and
* 7 days after the disappearance of symptoms for pauci-symptomatic subjects. Non-inclusion criteria: Pregnant women and children under the age of 18 will not be included.
3. Intervention: the intervention group will have vitamin D supplementation (200,000 IU / 1 mL of Cholecalciferol (1 ml) Oral form). Control group will have a placebo treatment (physiological saline).
4. Output: the negative RT-PCR date will be compared in the two groups.
5. Variables: we will study the socio-demographic characteristics (age, sex, level of study) and the recovery dates (dates of confirmation samples, disappearance of symptoms and control) the presence of hospitalization.
6. Sample size: for a gain of 07 days for healing, with 90% power and a 2-sided 0.05 significance level, 130 patients were required (65 in each group).

C. Allocation of interventions:

After a phone agreement, a doctor ensures the treatment distribution. D. Ethical considerations This survey will be carried out respecting the research ethical considerations: consent (free, informed, written, clear and loyal) anonymity; confidentiality; protection and assistance.

E. Study budget The Monastir University Hospital of Monastir will fund study (buying Vit D). F. Study schedule This interventional investigation will begin in July 2020. Patient monitoring will be carried out until the recovery date. (2 negative RT-PCR tests).

Conditions

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Covid19

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

A randomized clinical trial with 2 parallel arms and participant masking

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

the intervention group will have vitamin D supplementation (200,000 IU / 1 mL of Cholecalciferol (1 ml) Oral form).

Control group will have a placebo treatment (physiological saline).

Study Groups

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VITD

A single vial of Cholecalciferol (1 ml) (200,000 IU / 1 m), Oral form,

Group Type ACTIVE_COMPARATOR

Vit-D 0.2 MG/ML Oral Solution [Calcidol]

Intervention Type DRUG

ARM 1 : Cholecalciferol 200,000 IU / 1 mL .

Placebo

A single vial of physiological salin Oral form

Group Type PLACEBO_COMPARATOR

Physiological Irrigating Solution

Intervention Type DRUG

ARM 2 : placebo

Interventions

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Vit-D 0.2 MG/ML Oral Solution [Calcidol]

ARM 1 : Cholecalciferol 200,000 IU / 1 mL .

Intervention Type DRUG

Physiological Irrigating Solution

ARM 2 : placebo

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* patients with COVID 19 and having a positive RT-PCR at control in

* 14 days from confirmation of infection for asymptomatic subjects and
* 7 days after the disappearance of symptoms for pauci-symptomatic subjects