Research on the Relationship Between Cognitive Function Changes and Cerebrovascular Health in Patients With Coronary Heart Disease

NCT ID: NCT05848934

Last Updated: 2023-05-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-05-01

Study Completion Date

2025-12-31

Brief Summary

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The purpose of this study is to elucidate the imaging mechanisms of cognitive function changes in patients with coronary heart disease before and after surgery or conservative treatment, and to evaluate and predict the postoperative neurological function recovery and cerebrovascular health level of patients by combining serum markers and patient cardiovascular health evaluation indicators.

Detailed Description

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The focus of this study is to elucidate the impact of coronary heart disease on the morphology and cognitive changes of cerebral blood vessels in patients. Record imaging data, neuropsychological cognitive scales, serum markers, adverse cardiac events, and patient evaluation indicators before and after clinical treatment and follow-up period, and explore relevant factors affecting changes in cerebrovascular morphology and cognitive function.

Conditions

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Coronary Heart Disease Image

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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CAD(coronary heart disease )surgical treatment

magnetic resonance image

Intervention Type DEVICE

Imaging data were collected in a strong magnetic field

Neuropsychological scale

Intervention Type DIAGNOSTIC_TEST

Multi dimensional neuropsychological test

CAD(coronary heart disease )conservative treatment

magnetic resonance image

Intervention Type DEVICE

Imaging data were collected in a strong magnetic field

Neuropsychological scale

Intervention Type DIAGNOSTIC_TEST

Multi dimensional neuropsychological test

HC (Healthy controls)

magnetic resonance image

Intervention Type DEVICE

Imaging data were collected in a strong magnetic field

Neuropsychological scale

Intervention Type DIAGNOSTIC_TEST

Multi dimensional neuropsychological test

Interventions

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magnetic resonance image

Imaging data were collected in a strong magnetic field

Intervention Type DEVICE

Neuropsychological scale

Multi dimensional neuropsychological test

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Confirmed coronary heart disease or risk of coronary heart disease through clinical testing
* Conscious and capable of completing neuropsychological scales

Exclusion Criteria

* Patients with other serious heart diseases (such as aortic aneurysm)
* People with uncontrolled hypertension or diabetes
* There are contraindications to MRI examination (there are metal implants in the body, such as cardiac pacemakers, metal dentures, artificial joints, non paramagnetism stents, etc.; there is claustrophobia)
* Have a history of severe stroke, epilepsy, traumatic brain injury, and transient ischemic events
* Existence of neurological and mental disorders (schizophrenia, depression, etc.), post-traumatic stress disorder, obsessive-compulsive disorder, multiple sclerosis, amyotrophic lateral sclerosis, etc
* Have a history of alcohol or drug abuse
* Those with significant organ dysfunction such as lung, liver, and kidney;
* Patients with tumor, infectious diseases, blood system disease and immune system disease;
* Currently participating in other clinical studies at the same time.
Minimum Eligible Age

40 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Xi'an Jiaotong University

OTHER

Sponsor Role collaborator

Yuncheng First Hospital

UNKNOWN

Sponsor Role collaborator

Nanjing University of Traditional Chinese Medicine

OTHER

Sponsor Role lead

Responsible Party

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Qianyan Liu

Principal Investgator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Nengrui Guo

Role: PRINCIPAL_INVESTIGATOR

Yuncheng First Hospital

Locations

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Yuncheng First Hospital

Yuncheng, Shanxi, China

Site Status

Countries

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China

Central Contacts

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Nengrui Guo

Role: CONTACT

0086-17635599999

Lijun Bai, phD

Role: CONTACT

0086-15129034948

Other Identifiers

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82071993-1

Identifier Type: -

Identifier Source: org_study_id

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