Multimodal Imaging Assessment After Revascularization in Patients With Acute Myocardial Infarction

NCT ID: NCT07130409

Last Updated: 2025-08-19

Basic Information

• Recruitment Status: RECRUITING
• Total Enrollment: 20 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2025-08-31
• Study Completion Date: 2026-12-31

Brief Summary

This prospective cohort study will enroll 20 patients clinically diagnosed with first-time acute myocardial infarction (AMI) who underwent interventional procedures (including percutaneous coronary intervention [PCI] and balloon angioplasty) at the Affiliated Hospital of Qingdao University. Patient data, including routine blood and urine tests, blood biochemistry, electrocardiograms (ECG), imaging studies, and interventional procedure records, will be collected to assess eligibility for enrollment. The study procedures include patient screening and enrollment, obtaining informed consent, baseline assessment (including medical history, laboratory tests, ECG, etc.), an ¹⁸F-Pentixafor PET/MR examination, and follow-up. Images will be blindly assessed by at least two specialized physicians from the Radiology and Nuclear Medicine departments. The study aims to investigate the utility of ¹⁸F-Pentixafor PET/MR in evaluating coronary microcirculatory function, cardiac function, myocardial viability, myocardial inflammatory response, and the efficacy of interventional therapy in AMI patients post-procedure. Additionally, it will perform risk stratification and prognostic analysis for the enrolled patients.

Conditions

Cardiac Magnetic Resonance Imaging; Acute Myocardial Infarction (AMI); PET / MR

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

clinically diagnosed with first-episode AMI and undergoing interventional therapy

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Patients with a clinical diagnosis of first-episode acute myocardial infarction (AMI) who underwent emergency percutaneous coronary intervention (PCI) were included. All patients had complete baseline clinical data, with baseline cardiac magnetic resonance (CMR) examinations performed within 7 days post-PCI and follow-up CMR completed at 6 months post-procedure.

Exclusion Criteria

• Patients with severe cardiac decompensation (Killip class 4) or clinically unstable conditions.

Patients with coexisting valvular heart disease, congenital heart disease, pulmonary hypertension, cardiomyopathy, or persistent atrial fibrillation that may confound cardiac structural/functional assessments.

Prior history of myocardial infarction, coronary revascularization (PCI/CABG).

Concurrent severe systemic diseases including hematologic disorders, malignancies, rheumatic/autoimmune diseases, or severe hepatic/renal failure.

Contraindications to CMR (claustrophobia, pacemaker implantation, etc.).

Pregnant, breastfeeding, or women of childbearing potential without effective contraception.

Sexually active individuals of reproductive age unwilling to use reliable contraception.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

The Affiliated Hospital of Qingdao University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

The Affiliated Hospital of Qingdao University

Qingdao, Shandong, China

Site Status: RECRUITING

Countries

China

Central Contacts

Pei Nie, MD

Role: CONTACT

niepei@qdu.edu.cn

0532-82911500

Facility Contacts

Pei Nie

Role: primary

niepei@qdu.edu.cn

0532-82911500

Other Identifiers

QYFYECR2025-74

Identifier Type: -

Identifier Source: org_study_id