Clinical Significance of Subclinical Myocardial Involvement in Recovered COVID-19 Patients Using Cardiovascular Magnetic Resonance (R-COVID-CMR)
NCT ID: NCT04864899
Last Updated: 2025-05-11
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
112 participants
INTERVENTIONAL
2021-09-01
2024-08-06
Brief Summary
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Detailed Description
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1. Determine the extent of myocardial involvement of COVID-19, as assessed by Cardiovascular Magnetic Resonance (CMR), 2 weeks after patient recovery, at 3-month post discharge and at 1-year post discharge.
2. Correlate these myocardial characteristics to biventricular structure, function, blood biomarkers of inflammation, clinical symptoms, and functional capacity at all time points.
3. Follow up recovered COVID-19 patients beyond the end of this study to assess for hard outcomes such as death, heart failure hospitalization, cardiac arrest and ventricular tachycardia/ fibrillation.
Recovered COVID-19 patients and age and gender matched controls subjects will be recruited.
Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
DIAGNOSTIC
NONE
Study Groups
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Recovered COVID-19 patients
Cardiac Magnetic Resonance Imaging (CMR)
Imaging
Blood test
Blood investigation
6-minute walk test
Correlating the cardiac MRI parameters with functional capacity
Recovered non-COVID-19 viral respiratory infections patients
Cardiac Magnetic Resonance Imaging (CMR)
Imaging
Blood test
Blood investigation
6-minute walk test
Correlating the cardiac MRI parameters with functional capacity
Age and gender matched controls
Cardiac Magnetic Resonance Imaging (CMR)
Imaging
Blood test
Blood investigation
6-minute walk test
Correlating the cardiac MRI parameters with functional capacity
Interventions
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Cardiac Magnetic Resonance Imaging (CMR)
Imaging
Blood test
Blood investigation
6-minute walk test
Correlating the cardiac MRI parameters with functional capacity
Eligibility Criteria
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Inclusion Criteria
Definition of recovered COVID-19 patient:
* COVID-19 diagnosis = established by a positive reverse transcription polymerase chain reaction (RT-PCR) for severe acute respiratory syndrome coronavirus-2 \[SARS-CoV2\] and recovered from COVID-19.
* Recovery = based on two criteria: (1) two negative nasopharyngeal swab RT-PCR results \>24 hours apart and (2) absence of fever and improvement in respiratory symptoms.
* Recovered non-COVID-19 patients with viral respiratory infections confirmed with viral polymerase chain reaction testing AND with a confirmed negative COVID-19 RT-PCR test.
* Age and gender matched controls with no cardiac risk factors, not on cardiac medications, no history of myocardial infarction, heart failure or myocarditis, negative COVID-19 RT-PCR test and negative COVID-19 antibodies test.
Exclusion Criteria
* History of heart failure unrelated to COVID-19 infection
* Presence of pacemakers or implantable cardiac defibrillators
* Any contraindication for CMR testing
* Renal impairment with eGFR \<45ml/min/1.73m2
* Limited life expectancy \<1 year, for example due to pulmonary disease, cancer or significant hepatic failure
* Refusal or inability to sign an informed consent.
* Potential for non-compliance towards the requirements in the trial protocol (especially the medical treatment) or follow-up visits
ALL
Yes
Sponsors
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The University of Hong Kong
OTHER
Responsible Party
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Dr. Ng Ming-Yen
Clinical Assistant Professor
Locations
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The University of Hong Kong
Hong Kong, , Hong Kong
Countries
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Other Identifiers
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UW21-005
Identifier Type: -
Identifier Source: org_study_id
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