Effect of Transcranial Direct Current Stimulation (tDCS) on Post-stroke Patients on Neuromotor Recovery
NCT ID: NCT05821816
Last Updated: 2025-03-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
50 participants
INTERVENTIONAL
2023-03-02
2025-02-01
Brief Summary
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Detailed Description
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It will evaluate:
* baseline NfL levels in patients with subacute stroke;
* the correlation between motor recovery and the blood concentration of NfL in subjects treated with tDCS compared to the control group.
* the effect of tDCS on motor recovery and NfL levels in the 3 months after the stroke event;
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Experimental Group
Standard rehabilitative treatment for stroke + tDCS
tDCS
Use of Transcranial direct current stimulation for 20 minutes per day, 5 days a week, at 2mA
Conventional rehabilitative treatment
Physiotherapy treatment consisting in two treatments per day of 40 minutes each
Control Group
Only standard rehabilitative treatment for stroke
Conventional rehabilitative treatment
Physiotherapy treatment consisting in two treatments per day of 40 minutes each
Interventions
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tDCS
Use of Transcranial direct current stimulation for 20 minutes per day, 5 days a week, at 2mA
Conventional rehabilitative treatment
Physiotherapy treatment consisting in two treatments per day of 40 minutes each
Eligibility Criteria
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Inclusion Criteria
* partecipants must be enrolled within 30 days from the stroke
Exclusion Criteria
* uncooperative patients
* medically unstable patients
* partecipants with any other neurodegenerative diseases
* epilepsies
* multiple ischemic lesions
* encephalic trunk ischemic lesions
18 Years
100 Years
ALL
No
Sponsors
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I.R.C.C.S. Fondazione Santa Lucia
OTHER
Responsible Party
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Stefano Brunelli
MD, Physiatrist of the Operative Unit 4 for inpatient rehabilitation
Principal Investigators
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Stefano Brunelli, MD
Role: STUDY_DIRECTOR
I.R.C.C.S. Fondazione Santa Lucia, Roma, Italy
Locations
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I.R.C.C.S. Fondazione Santa Lucia
Roma, Italy, Italy
Countries
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References
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Allman C, Amadi U, Winkler AM, Wilkins L, Filippini N, Kischka U, Stagg CJ, Johansen-Berg H. Ipsilesional anodal tDCS enhances the functional benefits of rehabilitation in patients after stroke. Sci Transl Med. 2016 Mar 16;8(330):330re1. doi: 10.1126/scitranslmed.aad5651. Epub 2016 Mar 16.
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Collen FM, Wade DT, Robb GF, Bradshaw CM. The Rivermead Mobility Index: a further development of the Rivermead Motor Assessment. Int Disabil Stud. 1991 Apr-Jun;13(2):50-4. doi: 10.3109/03790799109166684.
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Khedr EM, Shawky OA, El-Hammady DH, Rothwell JC, Darwish ES, Mostafa OM, Tohamy AM. Effect of anodal versus cathodal transcranial direct current stimulation on stroke rehabilitation: a pilot randomized controlled trial. Neurorehabil Neural Repair. 2013 Sep;27(7):592-601. doi: 10.1177/1545968313484808. Epub 2013 Apr 22.
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Sattler V, Acket B, Raposo N, Albucher JF, Thalamas C, Loubinoux I, Chollet F, Simonetta-Moreau M. Anodal tDCS Combined With Radial Nerve Stimulation Promotes Hand Motor Recovery in the Acute Phase After Ischemic Stroke. Neurorehabil Neural Repair. 2015 Sep;29(8):743-54. doi: 10.1177/1545968314565465. Epub 2015 Jan 7.
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Other Identifiers
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Prot. CE/2022_031
Identifier Type: -
Identifier Source: org_study_id
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