Brain Stimulation Enhance Post-stroke Walking Survivors and Healthy Adults
NCT ID: NCT06191549
Last Updated: 2025-10-31
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ACTIVE_NOT_RECRUITING
NA
70 participants
INTERVENTIONAL
2025-05-01
2026-08-31
Brief Summary
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Detailed Description
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Aim 1: To explore the trends of locomotor skill acquisition in stroke survivors after anodal tDCS (a-tDCS, real brain stimulation), stroke survivors after sham tDCS (s-tDCS), and stroke with no brain stimulation (control; CON). Hypothesis (Aim 1): Stroke participants who receives a-tDCS will show a faster rate of learning a locomotor task compared to stroke participants who receive s-tDCS and stroke participants with no brain stimulation.
Aim 2: To explore different trends of stimulation-induced improvements in learning capacity and neural activities between three groups: stroke group, healthy young group, and healthy older group. Hypothesis (Aim 2): Healthy young adults will have a greater degree of stimulation-induced improvements in learning capacity and neural excitation compared to older adults and stroke participants.
Aim 3: To explore the trends of functional improvements post a-tDCS in stroke survivors. Hypothesis (Aim 3): Stroke participants who receives a-tDCS will show a greater improvements in functional performances compared to stroke participants who receive s-tDCS and stroke participants with no brain stimulation.
Aim 4: To explore the accumulated, longitudinal trends of a four-week visuomotor stepping training in conjunction with brain stimulation on treadmill walking training and gait improvements for persons with chronic stroke. Hypothesis (Aim 4): Stroke participants who receives a-tDCS will show a greater degree of gait improvements compared to stroke participants who receive s-tDCS and stroke participants with no brain stimulation.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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To explore the effect of brain stimulation on locomotor skill acquisition in stroke survivors
To explore the trends of locomotor skill acquisition in stroke survivors after anodal tDCS (a-tDCS, real brain stimulation), stroke survivors after sham tDCS (s-tDCS), and stroke with no brain stimulation (control; CON).
anodal transcranial direct current stimulation (a-tDCS)
Stroke participants will be randomly assigned into one of three groups: anodal transcranial direct current stimulation (a-tDCS), sham tDCS (s-tDCS), or control groups (i.e. no brain stimulation). Young and older healthy adults will be randomly assignments into a-tDCS or s-tDCS groups.
Stroke participants in each group will receive a four-week of the assigned brain stimulation combined with visuomotor stepping training and treadmill training
To explore improvements in learning capacity between healthy adults and stroke participants.
Compare stimulation-induced improvements in learning capacity between three groups: stroke group, healthy young group, and healthy older group.
anodal transcranial direct current stimulation (a-tDCS)
Stroke participants will be randomly assigned into one of three groups: anodal transcranial direct current stimulation (a-tDCS), sham tDCS (s-tDCS), or control groups (i.e. no brain stimulation). Young and older healthy adults will be randomly assignments into a-tDCS or s-tDCS groups.
Stroke participants in each group will receive a four-week of the assigned brain stimulation combined with visuomotor stepping training and treadmill training
To explore the trends of functional improvements after single a-tDCS session in stroke survivors.
To explore functional improvements (gait performance, brain neural activation) between a-tDCS, s-tDCS, and control groups.
anodal transcranial direct current stimulation (a-tDCS)
Stroke participants will be randomly assigned into one of three groups: anodal transcranial direct current stimulation (a-tDCS), sham tDCS (s-tDCS), or control groups (i.e. no brain stimulation). Young and older healthy adults will be randomly assignments into a-tDCS or s-tDCS groups.
Stroke participants in each group will receive a four-week of the assigned brain stimulation combined with visuomotor stepping training and treadmill training
To explore the accumulated effects of brain stimulation on gait improvements in stroke survivors
To explore the accumulated, longitudinal trends of a four-week visuomotor stepping training in conjunction with brain stimulation on treadmill walking training and gait improvements for persons with chronic stroke.
anodal transcranial direct current stimulation (a-tDCS)
Stroke participants will be randomly assigned into one of three groups: anodal transcranial direct current stimulation (a-tDCS), sham tDCS (s-tDCS), or control groups (i.e. no brain stimulation). Young and older healthy adults will be randomly assignments into a-tDCS or s-tDCS groups.
Stroke participants in each group will receive a four-week of the assigned brain stimulation combined with visuomotor stepping training and treadmill training
Interventions
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anodal transcranial direct current stimulation (a-tDCS)
Stroke participants will be randomly assigned into one of three groups: anodal transcranial direct current stimulation (a-tDCS), sham tDCS (s-tDCS), or control groups (i.e. no brain stimulation). Young and older healthy adults will be randomly assignments into a-tDCS or s-tDCS groups.
Stroke participants in each group will receive a four-week of the assigned brain stimulation combined with visuomotor stepping training and treadmill training
Eligibility Criteria
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Inclusion Criteria
* Medical history of a unilateral stroke occurring ≥ 6 months prior to enrollment
* MRI or CT evidence from the imaging report shown that the stroke involves the corticospinal tract
* Hemiparesis involving the lower extremity (Fugl-Meyer Lower Extremity Motor Test)
* No passive range of motion limitation in bilateral hips and knees
* Limitation of ankle passive range of motion to 10 degrees of dorsiflexion or less
* Visual acuity can be corrected by glasses or contact lens to 20/20
* Able to walk independently with/without assistant devices for 10 meters
* Able to maintain standing position without any assistance \>= 30 sec (Short Physical Performance Battery)
* Evaluation of cognitive status: Mini-mental status examination (MMSE) score ≥ 24
Exclusion Criteria
* MRI or CT evidence of involvement of the basal ganglia or cerebellum, evidence of multiple lesions, or evidence of any other brain damage or tumors
* Have any metal implants, cardiac pacemakers, or history of seizures
* Ongoing orthopedic or other neuromuscular disorders that will restrict exercise training
* Any vestibular dysfunction or unstable angina
* Significant cognitive deficits (inability to follow a 2-step command) or severe receptive or global aphasia
21 Years
90 Years
ALL
Yes
Sponsors
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The Claude D. Pepper Older Americans Independence Centers
OTHER
The University of Texas Medical Branch, Galveston
OTHER
Responsible Party
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Principal Investigators
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Shih-Chiao Tseng, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Texas
Locations
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University of Texas Medical Branch
Galveston, Texas, United States
Countries
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Other Identifiers
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21-0295
Identifier Type: -
Identifier Source: org_study_id
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