Cardiorespiratory Fitness, Apolipoprotein E Genotype, and Cognitive Functions: A Prospective Study

NCT ID: NCT05652140

Last Updated: 2024-11-15

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 159 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2018-07-01
• Study Completion Date: 2021-05-01

Brief Summary

The current research project aims to investigate the interaction of cardiorespiratory fitness (CRF) and the ApoE genotype with neurocognitive functions.

Detailed Description

The current research project aims to investigate the interaction of cardiorespiratory fitness (CRF) and the ApoE genotype with neurocognitive functions. The three main purposes of the current research project seek to achieve:

1. An exploration of the associations of, as well as the interactions between, CRF assessed at the Baseline Stage, and the ApoE genotype, along with cognitive functions in cognitively healthy late-middle-aged older adults.

2. The employing of an event-related potential (ERP) to investigate the associations between the baseline CRF, the ApoE genotype, and cognitive functions in cognitively healthy late-middle-aged older adults, as well as the potential underlying neuroelectrical mechanisms.

3. An investigation of the interactions between the changes of CRFs assessed at the Baseline and the Follow-Up Stages and the ApoE genotype in relation to neurocognitive function, as well as the underlying neuroelectrical mechanisms, in cognitively healthy late-middle-aged older adults.

Conditions

Aging; Cognitive Change

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

High-Risk with increased CRF

ApoE e4 carriers with increased CRF from Baseline to the Follow-Up Stages.

Data collections

Intervention Type: OTHER

Data collections of cognitive function, neuroelectrical activities, ApoE genotype, and physical fitness.

High-Risk with decreased CRF

ApoE e4 carriers with decreased CRF from Baseline to the Follow-Up Stages.

Data collections

Intervention Type: OTHER

Data collections of cognitive function, neuroelectrical activities, ApoE genotype, and physical fitness.

Low-Risk with increased CRF

Non-ApoE e4 carriers with increased CRF from Baseline to the Follow-Up Stages.

Data collections

Intervention Type: OTHER

Data collections of cognitive function, neuroelectrical activities, ApoE genotype, and physical fitness.

Low-Risk with decreased CRF

Non-ApoE e4 carriers with decreased CRF from Baseline to the Follow-Up Stages.

Data collections

Intervention Type: OTHER

Data collections of cognitive function, neuroelectrical activities, ApoE genotype, and physical fitness.

Interventions

Data collections

Data collections of cognitive function, neuroelectrical activities, ApoE genotype, and physical fitness.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• right handed
• no history of cardiorespiratory disease
• normal or corrected-to-normal vision based on the 20/20 standard
• no risk of performing physical activities, as measured by the Physical Activity Readiness Questionnaire

Exclusion Criteria

• the scores of Mini-Mental Status Examination (MMSE) < 25 and cognitively intact upon study entry
• history of psychiatric or neurological diseases
• color-blindness

• Minimum Eligible Age: 50 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

National Taiwan Normal University

OTHER

Sponsor Role: lead

Responsible Party

Yu-Kai Chang

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Yu-Kai Chang, Ph.D.

Role: STUDY_DIRECTOR

Department of Physical Education and Sport Sciences, National Taiwan Normal University

Locations

Department of Physical Education and Sport Sciences, National Taiwan Normal University

Taipei, , Taiwan

Countries

Taiwan

Provided Documents

Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

PACNL_APOE_PROSPECTIVE

Identifier Type: -

Identifier Source: org_study_id