Effect of Early Non-invasive Phrenic Nerve Stimulation on Weaning in Mechanically Ventilated Patients
NCT ID: NCT05629819
Last Updated: 2024-03-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
104 participants
INTERVENTIONAL
2023-01-01
2024-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
SINGLE
Study Groups
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PNS group
In addition to conventional respiratory therapy and pulmonary rehabilitation, neuromuscular electrical stimulator was used for PNS
* Device Settings Strength: Maximum current tolerated by the patient (0-100mA, commonly used below 13mA) ； Stimulation time: 1.0s; Frequency: 40Hz;
* Location: The stimulation electrodes were attached to the left and right sides of the neck under the outer margin of the sternocleidomastoid muscle 1/3; The reference electrodes were attached to the surface of both pectoralis major muscles.
* Treatment frequency: 30 at a time, Bid, until withdrawal/death/for 4 weeks.
Non-invasive phrenic nerve stimulation
Some studies have shown that PNS can relieve diaphragmatic atrophy and reverse diaphragmatic dysfunction.
conventional group
* conventional respiratory therapy and pulmonary rehabilitation, including airway management, early activity, and respiratory muscle training.
* No intervention
No interventions assigned to this group
Interventions
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Non-invasive phrenic nerve stimulation
Some studies have shown that PNS can relieve diaphragmatic atrophy and reverse diaphragmatic dysfunction.
Eligibility Criteria
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Inclusion Criteria
* MV time ≤48h;
* MV duration is expected to be ≥72h;
* The sternocleidomastoid region and pectoralis major region were completely exposed.
* Patients or family members are willing to sign informed consent and participate in the study.
Exclusion Criteria
* Neuromuscular disease (myasthenia gravis, etc.) or known anatomical abnormalities of the diaphragm;
* ECMO status;
* Hemodynamic instability;
* Uncorrected arrhythmias;
* Be pregnant;
* Clinical end-stage and palliative care patients.
18 Years
80 Years
ALL
No
Sponsors
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Bing Sun
OTHER
Responsible Party
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Bing Sun
professor of treatment
Principal Investigators
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Bing Sun, MD
Role: PRINCIPAL_INVESTIGATOR
Beijing Chao Yang Hospital
Locations
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Bing Sun
Beijing, Beijing Municipality, China
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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PNS in MV patients
Identifier Type: -
Identifier Source: org_study_id
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