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Microcirculation in Spontaneous Breathing Trial

NCT ID: NCT04711590

Last Updated: 2022-12-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

59 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-12-05

Study Completion Date

2022-09-30

Brief Summary

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Weaning ventilator support in critically ill patients is crucial. Both delayed extubation and unexpected early reintubation are harmful to the patients. Weaning parameters and spontaneous breathing trial are used to investigate the indication and predict the successful extubation. Hemodynamic stability and physical reserve are important indicators as well. Microcirculation parameters are known to be more sensitive to the change of hemodynamic status than macrocirculation parameters. We hypothesize that the change of sublingual microcirculation before and after spontaneous breathing trial is different between the the patients with successful extubation and the patients with failed extubation. Thus, this study measures sublingual microcirculation in patients receiving spontaneous breathing trial and record the extubation status (successful or failed). The microcirculation parameters before and after spontaneous breathing trial are compared between the the patients with successful extubation and the patients with failed extubation.

Detailed Description

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Conditions

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Critically Ill

Keywords

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ventilator weaning microcirculation

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Successful extubation

The patients pass the spontaneous breathing trial and are successful extubated without reintubation within 72 hours. .

Microcirculation examination

Intervention Type OTHER

Sublingual microcirculation images were recorded using an incident dark-field video microscope

Failed extubation

The patients pass the spontaneous breathing trial and are successful extubated with reintubation within 72 hours. .

Microcirculation examination

Intervention Type OTHER

Sublingual microcirculation images were recorded using an incident dark-field video microscope

Interventions

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Microcirculation examination

Sublingual microcirculation images were recorded using an incident dark-field video microscope

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* critically ill patients received ventilator longer than 12 hours
* ready for spontaneous breathing trial
* GCS coma score equal or higher than 8

Exclusion Criteria

* aged less than 20 years
* patient with tracheostomy
* patient and patients' relatives are non-native speakers
Minimum Eligible Age

20 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Taiwan University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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National Taiwan University Hospital

Taipei, , Taiwan

Site Status

Countries

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Taiwan

Other Identifiers

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201909036RINB

Identifier Type: -

Identifier Source: org_study_id