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Breathing Pattern, WOB and Gas Exchange in Patients With Acute Respiratory Distress Syndrome During the Spontaneous Breathing Trial

NCT ID: NCT04209270

Last Updated: 2019-12-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

37 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-04-01

Study Completion Date

2022-12-01

Brief Summary

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There is little evidence about the mechanical characteristics and muscular function in patients with Acute Respiratory Distress Syndrome (ARDS) at the time of weaning of the mechanical ventilation, as well as the behavior of the mechanical properties, breathing pattern, muscular effort, and gas exchange during a successful and failed spontaneous breathing trial.

Detailed Description

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The study of the respiratory system (RS) mechanics in patients with ARDS has been focused on the initial phase of ventilatory support, with few studies observing the weaning in mechanical ventilation.The RS in patients with ARDS is characterized by a greater or lesser degree of low functional residual capacity (FRC) in relation to normal.

At the time of performing a spontaneous breathing trial, these mechanical characteristics determine the need to develop a high transpulmonary pressure during each breath, with high work of breathing (WOB) to achieve adequate alveolar ventilation.

Inspiratory muscle weakness could alter the ability to generate the necessary transpulmonary pressure over time according to the loads imposed at the time of performing a spontaneous breathing trial, with the consequent development of fatigue and ventilatory failure.

This is why the investigators propose to evaluate the association between elastic WOB and the failure of the spontaneous breathing trial.

Conditions

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Work of Breathing ARDS Weaning Failure

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* over 18 years old
* requiring mechanical ventilation for more than 12 hours
* moderate/ severe ARDS according to Berlin Definition
* able to make a Spontaneous Breathing Trial according to the institution protocol

Exclusion Criteria

* pregnant patients
* history of neuromuscular disease
* patients in palliative care
* bronchopleural fistula
* contraindication of measurement of esophageal pressure
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sanatorio de la Trinidad Mitre

OTHER

Sponsor Role lead

Responsible Party

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María Lucía Gimenez

RT, Sanatorio de la Trinidad Mitre

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Sebastian Fredes, RT

Role: PRINCIPAL_INVESTIGATOR

Sanatorio de la Trinidad Mitre

Locations

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Sanatorio de la Trinidad Mitre

Buenos Aires, , Argentina

Site Status RECRUITING

Countries

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Argentina

Central Contacts

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Emilio Steinberg, RT

Role: CONTACT

Phone: 0054 91164977663

Email: [email protected]

Sebastian Fredes, RT

Role: CONTACT

Email: [email protected]

Facility Contacts

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Emilio Steinberg, RT

Role: primary

Sebastian Fredes, RT

Role: backup

Other Identifiers

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WOB in ARDS

Identifier Type: -

Identifier Source: org_study_id