Metabolic Risk Factors and Myocardial Oxygenation Reserve

NCT ID: NCT05574153

Last Updated: 2024-10-24

Basic Information

• Recruitment Status: RECRUITING
• Total Enrollment: 75 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2021-06-30
• Study Completion Date: 2024-12-30

Brief Summary

The purpose of this study is to use MRI images using the OS-CMR technique to view the differences in the hearts of healthy volunteers and participants with a condition called Metabolic Syndrome. The objectives of this project are to compare these two groups and to view how health risks, blood test results, and the time since a Metabolic diagnosis can affect heart health.

Detailed Description

Myocardial oxygenation changes during vasoactive breathing maneuvers, observed with oxygenation-sensitive cardiac MRI, will be identified and compared between individuals considered healthy and those fitting the criteria of the Metabolic Syndrome.

Conditions

Metabolic Syndrome

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Study Groups

Patient Participant

Participants with known Metabolic Syndrome (MetS)

Cardiac MRI

Intervention Type: DIAGNOSTIC_TEST

Participants will undergo an oxygenation-sensitive cardiac MRI and, during the scan, perform a vasoactive breathing maneuver composed of a period of paced hyperventilation followed by a voluntary maximal breath hold.

Healthy Volunteers

NonS-moking participants with no known pre-existing conditions and who do not take any medications

Cardiac MRI

Intervention Type: DIAGNOSTIC_TEST

Participants will undergo an oxygenation-sensitive cardiac MRI and, during the scan, perform a vasoactive breathing maneuver composed of a period of paced hyperventilation followed by a voluntary maximal breath hold.

Interventions

Cardiac MRI

Participants will undergo an oxygenation-sensitive cardiac MRI and, during the scan, perform a vasoactive breathing maneuver composed of a period of paced hyperventilation followed by a voluntary maximal breath hold.

Intervention Type: DIAGNOSTIC_TEST

Other Intervention Names

Breathing Maneuvers

Eligibility Criteria

Inclusion Criteria

Patient Participants:

• Age 18-80
• Informed Consent
• Diagnosis of MetS (through at least 3 MetS characteristics (abdominal obesity, high triglyceride level, low HDL cholesterol, high systolic blood pressure, and high fasting glucose levels)

Healthy Volunteers:

• Age 18-80
• No known current or pre-existing significant medical problems that would affect the cardiovascular or respiratory system
• No Smoking

Exclusion Criteria

• General MRI contraindications*
• Pacemakers, defibrillating wires, implanted defibrillators, intracranial aneurysm clips, metallic foreign bodies in the eyes, knowledge or suspicion of pregnancy.
• Consumption of caffeine (coffee, tea, cocoa, chocolate, "energy drink") during the 12 hours prior to the exam

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

McGill University Health Centre/Research Institute of the McGill University Health Centre

OTHER

Sponsor Role: lead

Responsible Party

Matthias Friedrich

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

The Reseach Institute of the McGill University Health Centre

Montreal, Quebec, Canada

Site Status: RECRUITING

Countries

Canada

Central Contacts

Katherine Lindsay, Master

Role: CONTACT

katherine.lindsay@mail.mcgill.ca

514-934-1934 ext. 37305

Elizabeth Konidis, Master

Role: CONTACT

elisavet.konidis@muhc.mcgill.ca

514-934-1934 ext. 37305

Facility Contacts

Katherine Lindsay, Master

Role: primary

katherine.lindsay@mail.mcgill.ca

514-9341934 ext. 37305

Other Identifiers

2021-7267

Identifier Type: -

Identifier Source: org_study_id