Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ACTIVE_NOT_RECRUITING
PHASE4
778 participants
INTERVENTIONAL
2023-02-06
2027-02-11
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
QUADRUPLE
Study Groups
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Sodium bicarbonate
50 ml of 1 mmol/ml sodium bicarbonate given as soon as possible after the first dose of adrenaline. If the patient remains in cardiac arrest, one additional dose of 50 ml of 1 mmol/ml sodium bicarbonate will be administered after the second dose of adrenaline dose for a maximum of two doses.
Sodium bicarbonate
Sodium bicarbonate 1 mmol/ml
Placebo
50 mL of 9 mg/mL NaCl ("normal saline") given as soon as possible after the first dose of adrenaline. If the patient remains in cardiac arrest, one additional dose of 50 mL of 9 mg/mL NaCl will be administered after the second dose of adrenaline dose for a maximum of two doses.
Sodium chloride
Sodium chloride 9 mg/mL
Interventions
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Sodium bicarbonate
Sodium bicarbonate 1 mmol/ml
Sodium chloride
Sodium chloride 9 mg/mL
Eligibility Criteria
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Inclusion Criteria
2. Age ≥ 18 years
3. Received at least one dose of adrenaline during cardiopulmonary resuscitation (CPR)
Exclusion Criteria
2. Prior enrollment in the trial
3. Invasive mechanical circulatory support at the time of the cardiac arrest
4. Known or suspected pregnancy at the time of the cardiac arrest
5. Known objection by the patient to participate in the trial
6. Clinical indication for bicarbonate administration
18 Years
ALL
No
Sponsors
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University of Aarhus
OTHER
Lars Wiuff Andersen
OTHER
Responsible Party
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Lars Wiuff Andersen
Associate Professor
Principal Investigators
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Lars W Andersen
Role: PRINCIPAL_INVESTIGATOR
Aarhus University Hospital
Locations
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Hospital of Southern Jutland - Aabenraa
Aabenraa, , Denmark
Aalborg University Hospital
Aalborg, , Denmark
Aarhus University Hospital
Aarhus, , Denmark
Copenhagen University Hospital - Bispebjerg
Bispebjerg, , Denmark
Copenhagen University Hospital - Rigshospitalet
Copenhagen, , Denmark
Hospital of Southwest Jutland - Esbjerg
Esbjerg, , Denmark
Copenhagen University Hospital - Gentofte
Gentofte Municipality, , Denmark
Gødstrup Hospital
Gødstrup, , Denmark
Copenhagen University Hospital - Herlev
Herlev, , Denmark
North Denmark Region Hospital - Hjørring
Hjørring, , Denmark
Holbæk Hospital
Holbæk, , Denmark
Horsens Regional Hospital
Horsens, , Denmark
Hvidovre Hospital
Hvidovre, , Denmark
Kolding Hospital
Kolding, , Denmark
Zealand University Hospital - Køge
Køge, , Denmark
Nykøbing Falster Hospital
Nykøbing Falster, , Denmark
Odense University Hospital
Odense, , Denmark
Randers Regional Hospital
Randers, , Denmark
Zealand University Hospital - Roskilde
Roskilde, , Denmark
Slagelse Hospital
Slagelse, , Denmark
Odense University Hospital - Svendborg
Svendborg, , Denmark
Viborg Regional Hospital
Viborg, , Denmark
Countries
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Other Identifiers
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00004
Identifier Type: -
Identifier Source: org_study_id
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