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Bicarbonate in Patients With Out-of-hospital Cardiac Arrest

NCT ID: NCT02303548

Last Updated: 2022-03-25

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-10-31

Study Completion Date

2016-02-29

Brief Summary

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A pilot study to evaluate the effect of sodium bicarbonate administration on cardiopulmonary resuscitation results and outcomes in cardiac arrest patient with severe metabolic acidosis.

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Detailed Description

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Conditions

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Cardiac Arrest Metabolic Acidosis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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1 (Sodium bicarbonate)

Sodium bicarbonate 50cc (50mEq) intravenous injection over 2 min

Group Type EXPERIMENTAL

Sodium bicarbonate

Intervention Type DRUG

Administer Sodium bicarbonate 50 mEq IV over 2 minutes

2 (Normal saline)

Normal saline 50cc intravenous injection over 2 min

Group Type PLACEBO_COMPARATOR

Normal saline

Intervention Type DRUG

Placebo

Interventions

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Sodium bicarbonate

Administer Sodium bicarbonate 50 mEq IV over 2 minutes

Intervention Type DRUG

Normal saline

Placebo

Intervention Type DRUG

Other Intervention Names

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Bivon 0.9% sodium chloride

Eligibility Criteria

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Inclusion Criteria

* adult cardiac arrest patient with arterial pH \<7.1 or bicarbonate \<10mmEq/L checked at 10 minutes of cardiopulmonary resuscitation

Exclusion Criteria

* age \<18 trauma patient Do Not Resuscitate state
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Asan Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Won Young Kim

Associate proffesor

Responsibility Role PRINCIPAL_INVESTIGATOR

References

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Ahn S, Kim YJ, Sohn CH, Seo DW, Lim KS, Donnino MW, Kim WY. Sodium bicarbonate on severe metabolic acidosis during prolonged cardiopulmonary resuscitation: a double-blind, randomized, placebo-controlled pilot study. J Thorac Dis. 2018 Apr;10(4):2295-2302. doi: 10.21037/jtd.2018.03.124.

Reference Type DERIVED
PMID: 29850134 (View on PubMed)

Other Identifiers

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BicarbonateinCPR001

Identifier Type: -

Identifier Source: org_study_id

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