Strategies for Defibrillation During Out-of-Hospital Cardiac Arrest

NCT ID: NCT06781892

Last Updated: 2025-05-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

909 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-03-15

Study Completion Date

2029-03-01

Brief Summary

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The "Strategies for Defibrillation during Out-of-Hospital Cardiac Arrest" (STRAT-DEFI) trial is an investigator-initiated, individually randomized, 3-group clinical trial comparing standard anterior-lateral pad positioning with anterior-posterior positioning and double sequential defibrillation during adult out-of-hospital cardiac arrest.

Detailed Description

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Conditions

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Cardiac Arrest (CA)

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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Anterior-lateral pad positioning

Group Type ACTIVE_COMPARATOR

Anterior-lateral pad positioning

Intervention Type OTHER

Defibrillation pads positioned anterior-lateral

Anterior-posterior pad positioning

Group Type EXPERIMENTAL

Anterior-posterior pad positioning

Intervention Type OTHER

Defibrillation pads positioned anterior-posterior

Double-sequential defibrillation

Anterior-lateral pad positioning combined with anterior-posterior pad positioning for a total of 4 pads and 2 shocks.

Group Type EXPERIMENTAL

Double-sequential defibrillation

Intervention Type OTHER

Combination of anterior-lateral and anterior-posterior pad positioning for a total of 4 pads and 2 shocks.

Interventions

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Anterior-lateral pad positioning

Defibrillation pads positioned anterior-lateral

Intervention Type OTHER

Anterior-posterior pad positioning

Defibrillation pads positioned anterior-posterior

Intervention Type OTHER

Double-sequential defibrillation

Combination of anterior-lateral and anterior-posterior pad positioning for a total of 4 pads and 2 shocks.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Out-of-hospital cardiac arrest
2. Age ≥ 18 years
3. ≥ 1 manual defibrillation attempt by emergency medical services
4. Shockable rhythm as the last known rhythm
5. Two manual defibrillators present on-site

Exclusion Criteria

1. Blunt trauma, penetrating trauma, or burn injury suspected to be the cause of the cardiac arrest
2. Prior enrollment in the trial
3. Posterior pad placement not deemed possible by on-site clinician
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Aarhus

OTHER

Sponsor Role collaborator

Lars Wiuff Andersen

OTHER

Sponsor Role lead

Responsible Party

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Lars Wiuff Andersen

Professor

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Emergency Medical Services, the North Denmark Region

Aalborg, , Denmark

Site Status RECRUITING

Danish Air Ambulance, Danish Regions

Aarhus N, , Denmark

Site Status NOT_YET_RECRUITING

Prehospital Emergency Medical Services, Central Denmark Region

Aarhus N, , Denmark

Site Status RECRUITING

Copenhagen Emergency Medical Services, the Capital Region of Denmark

Ballerup Municipality, , Denmark

Site Status NOT_YET_RECRUITING

The Prehospital Center, Region Zealand

Næstved, , Denmark

Site Status NOT_YET_RECRUITING

Emergency Medical Services, the Region of Southern Denmark

Vejle, , Denmark

Site Status NOT_YET_RECRUITING

Countries

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Denmark

Central Contacts

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Lars W Andersen

Role: CONTACT

+4578414848

Bertram L Kirkegaard

Role: CONTACT

Facility Contacts

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Thomas L Klitgaard

Role: primary

+4597662100

Jacob Steinmetz

Role: primary

+4578414936

Bertram L Kirkegaard

Role: primary

+4578414848

Fredrik Folke

Role: primary

+4538665000

Helle C Christensen

Role: primary

+4557684100

Søren Mikkelsen

Role: primary

+4576631000

Other Identifiers

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00006

Identifier Type: -

Identifier Source: org_study_id

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