Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
17 participants
INTERVENTIONAL
2014-08-31
2019-02-28
Brief Summary
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In the study measurements of changes in blood and urine concentrations of Sodium and Chloride as well as blood hemoglobin are used to mathematically calculate changes in distribution volumes of these different endogenous markers.
Detailed Description
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Before, during and after this infusion regular blood samples(and urine) are collected (0, 10, 20, 30, 35, 40, 45, 50, 60, 120, 180 and 300 minutes after infusion start).
B-Hemoglobin, P-Albumine, B-Glucose, P-Sodium, P-Potassium. P-Chlorides, U-Sodium, U-Chloride and U-Glucose. Hourly volume of urine is measured.
The 30 minute infusion can be used to calculate the urine extracellular volume. Thereafter during infusion of Ringers acetate changes in electrolytes in blood as well as urine volume and in the urine excreted electrolytes can be used to calculate the fluid shifts between the different fluid compartments.
Eventually 8 to 12 hours later a second infusion of SodiumChloride is as a control performed.
Conditions
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Keywords
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Study Design
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NA
SINGLE_GROUP
OTHER
NONE
Study Groups
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Ketoacidosis
Patients treated for diabetic ketoacidosis at the Intensive care unit, Vrinnevi Hospital, Norrköping.
SodiumChloride
Infusion of SodiumChloride, blood samples to calculate extracellular volume.
Interventions
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SodiumChloride
Infusion of SodiumChloride, blood samples to calculate extracellular volume.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
17 Years
80 Years
ALL
No
Sponsors
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Vrinnevi Hospital
OTHER
University Hospital, Linkoeping
OTHER
Responsible Party
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Joachim Zdolsek
MD, Associate Professor
Principal Investigators
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Robert Hahn, Prof
Role: STUDY_DIRECTOR
Linkoeping University
Locations
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Vrinnevi Hospital
Norrköping, Östergötland County, Sweden
Countries
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References
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Svensson R, Hahn RG, Zdolsek JH, Bahlmann H. Plasma volume expansion reveals hidden metabolic acidosis in patients with diabetic ketoacidosis. Intensive Care Med Exp. 2022 Dec;10(1):36. doi: 10.1186/s40635-022-00464-5. Epub 2022 Aug 29.
Other Identifiers
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FDKA
Identifier Type: -
Identifier Source: org_study_id