Colloid Osmotic Pressure and Osmolality in Hyponatremia

NCT ID: NCT03703713

Last Updated: 2024-05-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

1 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-10-09

Study Completion Date

2020-12-31

Brief Summary

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Hyponatremia (serum sodium of less than 135 mmol/L)is a very common electrolyte disorder. The reasons for the disorder varies as well as if it is acute or chronic.

In this study we wish to follow changes in colloid osmotic pressure and osmolality during the initial treatment hours. We also wish to use mass balance for the calculation of body compartments and to detect fluid translocation between these.

Detailed Description

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Patients with hyponatremia arriving att the intensive care unit are asked to participate in the study. The first blood samples are collected before initializing the treatment as well as measurements of body compartments with a bioimpedance analyzer. Collected blood samples are electrolytes (Sodium, Potassium and Chloride), colloid osmotic pressure, osmolality and hemoglobin. These samples are repeated at 4 and 8 hours after start of the study. Amount of infused fluid as well as electrolytes are recorded. Urine volume is measured and urine samples are analyzed for the loss of electrolytes.

Additional samples for guidance of treatment are collected every hour.

Hopefully the addition of colloid osmotic pressure, osmolality and mass balance can be beneficial in the diagnosis of the reason for the disorder as well as for the treatment.

Conditions

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Hyponatremia

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Hyponatremia

Patients treated for hyponatremia (\<125 mmol/L Sodium) in the intensive care department.

Sodium chloride

Intervention Type DRUG

Treatment with Sodium chloride

Interventions

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Sodium chloride

Treatment with Sodium chloride

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients treated for Hyponatremia at the intensive care unit.

Exclusion Criteria

* Circulatory instable patients in need of treatment for more than the hyponatremia.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Linkoeping

OTHER

Sponsor Role lead

Responsible Party

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Joachim Zdolsek

MD, PhD, Assoc prof, consultant

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Intensive Care Unit, Vrinnevi Hospital

Norrköping, , Sweden

Site Status

Countries

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Sweden

Other Identifiers

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COOH

Identifier Type: -

Identifier Source: org_study_id

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