Effect of Intravenous Lidocaine on Serum miRNA-135a in Patients Undergoing Non-cardiac Surgery
NCT ID: NCT05503043
Last Updated: 2022-08-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
50 participants
INTERVENTIONAL
2022-09-01
2023-12-30
Brief Summary
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Detailed Description
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Rock2 and Add1, which are regulated by miRNA-135a, play a key role in learning, memory, and cognition.
The objective of this study is to investigate the efficacy of intravenous lidocaine on the incidence of early POCD, and the levels of Rock2, Add1, and miRNA-135a in elderly patients undergoing non-cardiac under general anesthesia.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
DOUBLE
Study Groups
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Lidocaine
Intravenous bolus of 1.5 mg/kg of lidocaine followed by a continuous infusion of 3.0 mg/kg for the first hour, 1.5 mg/kg for the second hour, 0.7 mg/kg until the end of the surgery.
Lidocaine
Intravenous bolus of 1.5 mg/kg of lidocaine followed by a continuous infusion of 3.0 mg/kg for the frst hour, 1.5 mg/kg for the second hour, 0.7 mg/kg until the end of the surgery.
Normal saline
Normal saline administered as a bolus and an infusion with identical volume and rate changes as the treatment group.
Normal saline
Patients are received equal volumes of saline intravenously until the end of the surgery
Interventions
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Lidocaine
Intravenous bolus of 1.5 mg/kg of lidocaine followed by a continuous infusion of 3.0 mg/kg for the frst hour, 1.5 mg/kg for the second hour, 0.7 mg/kg until the end of the surgery.
Normal saline
Patients are received equal volumes of saline intravenously until the end of the surgery
Eligibility Criteria
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Inclusion Criteria
* ASA physical status II-III
* Aged ≥65 years
Exclusion Criteria
* Central nervous system injury
* Mental illness and drug dependence
* On regular use of analgesic/sedative/antidepressant
* Unable to cooperate
* Allergy to lidocaine
* MMSE \< 23 points
65 Years
80 Years
ALL
No
Sponsors
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General Hospital of Ningxia Medical University
OTHER
Responsible Party
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Principal Investigators
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Li Zhao
Role: PRINCIPAL_INVESTIGATOR
General Hospital of Ningxia Medical University
Central Contacts
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Other Identifiers
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Li-Zhao
Identifier Type: -
Identifier Source: org_study_id
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