MedDataX Logo

Effects of Epidural Local Anesthetics on Propofol Induction

NCT ID: NCT02000973

Last Updated: 2014-05-16

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

View full results

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

80 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-11-30

Study Completion Date

2014-03-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The investigators designed a prospective, randomized, placebo-controlled study to determine whether thoracic epidural anesthesia(TEA) with different local anesthetics has different influences on the propofol dose during induction.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

The Effect of Combined Ephedrine and Lidocaine Pretreatment on Pain and Hemodynamic Changes Due to Propofol Injection

NCT01186549

Pain Due to Propofol Injection Hemodynamic Changes Due to Propofol Injection
COMPLETED PHASE1/PHASE2

The Study of Perioperative Intravenous Infusion of Lidocaine on Postoperative Analgesia in Patients Undergoing Single-port Thoracoscopic

NCT04043624

Surgery
UNKNOWN PHASE4

Effect of Thoracic Epidural Analgesia on Intravenous Closed-Loop Anesthesia

NCT00627081

General Anesthesia
COMPLETED PHASE4

Comparison of Chloroprocaine vs Lidocaine for Epidural Anesthesia in Cesarean Delivery

NCT03414359

Surgical Anesthesia, Cesarean Section
COMPLETED EARLY_PHASE1

Extrapleural Intercostal Catheter vs. Thoracic Epidural for Thoracotomy Pain

NCT00373633

THoracotomy
TERMINATED PHASE1

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

General Anesthesia Propofol Target-controlled Infusion Thoracic Epidural Anesthesia

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Normal saline

General anesthesia combined with thoracic epidural 0.9% normal saline 8ml

Group Type PLACEBO_COMPARATOR

Normal Saline

Intervention Type DRUG

General anesthesia combined with thoracic epidural 0.9% normal saline

Lidocaine

General anesthesia combined with thoracic epidural 1% lidocaine 8ml

Group Type EXPERIMENTAL

Lidocaine

Intervention Type DRUG

General anesthesia combined with thoracic epidural 1% lidocaine

Bupivacaine

General anesthesia combined with thoracic epidural 0.25% bupivacaine 8ml

Group Type EXPERIMENTAL

Bupivacaine

Intervention Type DRUG

General anesthesia combined with thoracic epidural 0.25% bupivacaine

Ropivacaine

General anesthesia combined with thoracic epidural 0.3% ropivacaine 8ml

Group Type EXPERIMENTAL

Ropivacaine

Intervention Type DRUG

General anesthesia combined with thoracic epidural 0.3% ropivacaine

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Lidocaine

General anesthesia combined with thoracic epidural 1% lidocaine

Intervention Type DRUG

Bupivacaine

General anesthesia combined with thoracic epidural 0.25% bupivacaine

Intervention Type DRUG

Ropivacaine

General anesthesia combined with thoracic epidural 0.3% ropivacaine

Intervention Type DRUG

Normal Saline

General anesthesia combined with thoracic epidural 0.9% normal saline

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

Surgery for thoracotomies, BMI: 18-25 Kg/m2, American Society of Anesthesiologists(ASA) classification I or II.

Exclusion Criteria

liver or kidney disease, alcohol dependence, take sedative recently, contraindications for epidural anesthesia.
Minimum Eligible Age

45 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

First Hospital of China Medical University

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Jun Wang

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Jun Wang

Role: STUDY_CHAIR

Dept. of Anesthesiology, First Hospital of China Medical University

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

20131012

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Magnesium Versus High Dose Fentanyl in Endotracheal Intubation
NCT04544163 COMPLETED NA
Continuous Wound Catheter Analgesia Associated With Intravenous Morphine PCA After Thoracotomy
NCT01698203 COMPLETED PHASE4
Comparison of Three Different Strategies to Prevent Propofol Induced Pain During Infusion
NCT00146926 UNKNOWN PHASE3
The Impact of Intrapleural Block on Postoperative Pain Caused by Drainage Tubes After Thoracoscopic Surgery
NCT07294755 NOT_YET_RECRUITING NA
Epidural Anesthesia With Chloroprocaine Versus Lidocaine
NCT02287870 COMPLETED PHASE4
Ultrasound-guided Thoracic Paravertebral Block Using Ropivacaine With/Without Dexamethasone in Elective Thoracotomy
NCT02871193 COMPLETED NA
The Effective Concentration of Lidocaine With Fentanyl in Lumbar Epidural Anesthesia for Transurethral Resection of Prostate(TURP) in Elderly Patients
NCT01892332 COMPLETED NA
Intravenous Lidocaine Infusion Reduce Postoperative Pulmonary Complications in Patients Undergoing Minimally Invasive Esophagectomy
NCT06138041 NOT_YET_RECRUITING NA
Perioperative Epidural Versus Intravenous Local Anesthetic Infusion in Open Upper Abdominal Surgery
NCT03005171 COMPLETED PHASE2/PHASE3
Epidural Volume Extension and Intrathecal Use of Local Anesthetics in Cesarean Sections
NCT01558713 UNKNOWN PHASE2/PHASE3
A Randomised Comparison on the Dose Requirement Between, Levobupivacaine, Ropivacaine and Bupivacaine in Intrathecal Anaesthesia
NCT00636974 COMPLETED NA
Lidocaine-based Versus Opioid-based Induction of Anesthesia in Emergency Laparotomy
NCT06772727 RECRUITING PHASE4
The Effect of Intravenous Lidocaine on Pain After Thyroidectomy
NCT01608360 UNKNOWN PHASE4
Perioperative Lidocaine Administration in Thoracoscopic Surgery for Improved Postoperative Pain Control
NCT03677817 COMPLETED PHASE3
Intra-Peritoneal Local Anaesthesia After Cytoreductive Surgery
NCT02256228 COMPLETED PHASE3
Adjuvants With Intrathecal Bupivacaine for Postoperative Analgesia
NCT06082232 UNKNOWN PHASE4
Impact of Lidocaine Administration on Postoperative Complications During Lung Resection Surgery
NCT03905837 COMPLETED PHASE4
Bupivacaine, Levobupivacaine and Ropivacaine After Intrathecal and Extradural Injection in Labour
NCT01201213 TERMINATED PHASE4
A Study of Bupivacaine Liposome Injection in the Treatment of Pain After Thoracoscopic Surgery
NCT06529432 NOT_YET_RECRUITING PHASE2
Block and Erector Comparative Study Between Costotransverse Spinae Plane Block in Patients Undergoing Thoracotomy
NCT06301334 NOT_YET_RECRUITING NA
Minimum Effective Dose (MED) & Epidural Bupivacaine
NCT02116842 UNKNOWN PHASE4
Analgesic Effect of Perioperative Systemic Lidocaine in Patients Undergoing Unilateral Mastectomy Surgery
NCT00913003 TERMINATED PHASE4
Patient-Titrated Automated Intermittent Boluses of Local Anesthetic vs. a Continuous Infusion Via a Perineural Catheter for Postoperative Analgesia
NCT05091905 ENROLLING_BY_INVITATION PHASE4
Blood Ropivacaine Concentrations Following Chest Wall Nerve Block Continuous Infusion
NCT02860091 ACTIVE_NOT_RECRUITING
Evaluation of Plasma Concentrations of Intravenous Lidocaine and Epidural Ropivacaine When Used in Combination in Major Abdominal Surgery
NCT05368753 COMPLETED PHASE4