Epidural Anesthesia With Chloroprocaine Versus Lidocaine
NCT ID: NCT02287870
Last Updated: 2014-11-11
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE4
120 participants
INTERVENTIONAL
2008-01-31
2008-06-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
DOUBLE
Study Groups
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Chloroprocaine Group
Epidural anesthesia with 3% chloroprocaine.
Chloroprocaine
60 patients undergoing lower limb or lower abdominal surgery from three hospitals in China received 3% chloroprocaine.
Lidocaine Group
Epidural anesthesia with 2% lidocaine.
Lidocaine
60 patients undergoing lower limb or lower abdominal surgery from three hospitals in China received 2% lidocaine.
Interventions
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Chloroprocaine
60 patients undergoing lower limb or lower abdominal surgery from three hospitals in China received 3% chloroprocaine.
Lidocaine
60 patients undergoing lower limb or lower abdominal surgery from three hospitals in China received 2% lidocaine.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* American Society of Anesthesiologists (ASA) grade I or II
* No obstacles in thinking or language communication
* No epidural puncture contraindications such as disturbances of blood coagulation, local infection of the puncture site or use of anticoagulants
Exclusion Criteria
* Serious heart, liver, renal and metabolic diseases
* Cerebral thrombosis and sequela
* Serious dehydration and electrolyte imbalance
* Neuromuscular diseases
* Pregnant or parturient women
* Abnormal liver and kidney function
18 Years
60 Years
ALL
No
Sponsors
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Jinling Hospital, China
OTHER
Responsible Party
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Haibin Dai
Attending Doctor of Department of Anesthesiology
Principal Investigators
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Weiyan Li, M.D.
Role: STUDY_DIRECTOR
School of Medicine, Nanjing University
References
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FOLDES FF, McNALL PG. 2-Chloroprocaine: a new local anesthetic agent. Anesthesiology. 1952 May;13(3):287-96. doi: 10.1097/00000542-195205000-00009. No abstract available.
Steinemann TL, Sheikholeslami RR, Klein EF, Prokopius MJ. Short-acting peribulbar anesthesia with 2-chloroprocaine. J Cataract Refract Surg. 2002 Jan;28(1):195-6. doi: 10.1016/s0886-3350(01)00899-9.
Hadzic A, Arliss J, Kerimoglu B, Karaca PE, Yufa M, Claudio RE, Vloka JD, Rosenquist R, Santos AC, Thys DM. A comparison of infraclavicular nerve block versus general anesthesia for hand and wrist day-case surgeries. Anesthesiology. 2004 Jul;101(1):127-32. doi: 10.1097/00000542-200407000-00020.
Liu SS, Ware PD, Rajendran S. Effects of concentration and volume of 2-chloroprocaine on epidural anesthesia in volunteers. Anesthesiology. 1997 Jun;86(6):1288-93; discussion 7A. doi: 10.1097/00000542-199706000-00009.
Sell A, Tein T, Pitkanen M. Spinal 2-chloroprocaine: effective dose for ambulatory surgery. Acta Anaesthesiol Scand. 2008 May;52(5):695-9. doi: 10.1111/j.1399-6576.2008.01639.x.
Marica LS, O'Day T, Janosky JE, Nystrom EU. Chloroprocaine is less painful than lidocaine for skin infiltration anesthesia. Anesth Analg. 2002 Feb;94(2):351-4, table of contents. doi: 10.1097/00000539-200202000-00022.
Marsch SC, Sluga M, Studer W, Barandun J, Scharplatz D, Ummenhofer W. 0.5% versus 1.0% 2-chloroprocaine for intravenous regional anesthesia: a prospective, randomized, double-blind trial. Anesth Analg. 2004 Jun;98(6):1789-1793. doi: 10.1213/01.ANE.0000116929.45557.CE.
Jafari S, Kalstein AI, Nasrullah HM, Hedayatnia M, Yarmush JM, SchianodiCola J. A randomized, prospective, double-blind trial comparing 3% chloroprocaine followed by 0.5% bupivacaine to 2% lidocaine followed by 0.5% bupivacaine for interscalene brachial plexus block. Anesth Analg. 2008 Nov;107(5):1746-50. doi: 10.1213/ane.0b013e318185cd5e.
Bjornestad E, Iversen OL, Raeder J. Similar onset time of 2-chloroprocaine and lidocaine + epinephrine for epidural anesthesia for elective Cesarean section. Acta Anaesthesiol Scand. 2006 Mar;50(3):358-63. doi: 10.1111/j.1399-6576.2006.00937.x.
Casati A, Fanelli G, Danelli G, Berti M, Ghisi D, Brivio M, Putzu M, Barbagallo A. Spinal anesthesia with lidocaine or preservative-free 2-chlorprocaine for outpatient knee arthroscopy: a prospective, randomized, double-blind comparison. Anesth Analg. 2007 Apr;104(4):959-64. doi: 10.1213/01.ane.0000258766.73612.d8.
Other Identifiers
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2007NLY-004
Identifier Type: -
Identifier Source: org_study_id