A Study of Bupivacaine Liposome Injection in the Treatment of Pain After Thoracoscopic Surgery

NCT ID: NCT06529432

Last Updated: 2024-07-31

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: PHASE2
• Total Enrollment: 96 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-08-21
• Study Completion Date: 2026-10-12

Brief Summary

The objective of this study is to evaluate the efficacy, safety, and tolerability of bupivacaine liposomes for paravertebral nerve block in the treatment of thoracoscopic postoperative pain, and to evaluate the relevant human pharmacokinetics.

Conditions

Local Analgesia Via Nerve Block

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: TRIPLE

Study Groups

Bupivacaine Liposome Injection

Group Type: EXPERIMENTAL

Bupivacaine Liposome Injection

Intervention Type: DRUG

Bupivacaine Liposome Injection Low Dose or Moderate Dose or High Dose

Bupivacaine Hydrochloride Injection

Group Type: ACTIVE_COMPARATOR

Bupivacaine Hydrochloride Injection

Intervention Type: DRUG

Bupivacaine Hydrochloride Injection Low Dose or Moderate Dose or High Dose

Interventions

Bupivacaine Liposome Injection

Bupivacaine Liposome Injection Low Dose or Moderate Dose or High Dose

Intervention Type: DRUG

Bupivacaine Hydrochloride Injection

Bupivacaine Hydrochloride Injection Low Dose or Moderate Dose or High Dose

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

-

1. Subjects who are willing to strictly follow the clinical trial protocol to complete this study and voluntarily sign informed consent;

2. Elective surgical subjects undergoing lobectomy by single-aperture thoracoscope under general anesthesia;

3. age ≥18 years old , Male or female.

4. 18 kg/m2≤BMI≤30 kg/m2.

5. ASA Physical Status Classification I-II.

Exclusion Criteria

• Participants with any of the following criteria were excluded from the study：

1. Pre-existing and combined diseases:

1. Subjects with a history of myocardial infarction or unstable angina pectoris, or a history of severe arrhythmias such as atrioventricular block of degree II and above, or NYHA grade II and above in the 6 months before randomization.

2. Subjects with a history of ischemic stroke or transient ischemic attack (TIA).

3. Subjects with psychiatric disorders (such as schizophrenia, depression, etc.) and cognitive dysfunction.

4. Subjects with sensory disorders such as hyperalgesia.

5. Subjects with other physical pain witch may affect the evaluation of postoperative pain.

6. Subjects with airway or spinal anatomic factors caused by obstruction of ventilation, bronchiectasis, severe intraoperative thoracic adhesion, etc.

2. Laboratory and other tests:

1. Abnormal laboratory results during screening. • Fasting blood glucose (FPG) ≥10.0mmol/L.

• Abnormal liver function: aspartate aminotransferase (AST) or/and alanine aminotransferase (ALT) and/or total bilirubin (TBIL) ≥1.5×ULN.

• Abnormal renal function: serum creatinine (Cr) ≥1.5×ULN, or dialysis subjects.

• Abnormal coagulation function: PT> upper normal value +3s and/or APTT > upper normal value +10s.

• Platelet (PLT) <80×109/L.

• Hemoglobin concentration (Hb) < 70g/L.

2. Screening period heart rate < 50 beats/min or heart rate > 100 beats/min; 12-lead ECG QTc interval prolonged: male ≥450ms, female ≥470ms.

3. Subjects with refractory hypertension or a history of refractory hypertension before randomization.

3. Combined drugs:

(1) Subjects who allergic to or contraindicated with bupivacaine, other amide local anesthetics, and other drugs that may be used during the trial (e.g., propofol, remazolam, opioids, etc.).

(2) Subjects who used any of the following drugs within 5 drug half-lives prior before randomization (drug half-lives are based on actual drug instructions, or at least 48 hours of elution if half-lives are unknown):

• Class III antiarrhythmic drugs such as amiodarone.
• Drugs that affect liver metabolism: strong CYP1A2 inhibitors such as ciprofloxacin, enoxacin, fluvoxamine; CYP1A2 substrates: such as theophylline, imipramine; Strong CYP3A4 inhibitors such as voriconazole, ketoconazole, Ritonavir; CYP3A4 substrates such as darunavir, Indinavir, saquinavir; Strong CYP3A4 inducers such as rifampin.
• Intravenous or oral corticosteroids.
• Sedative drugs: benzodiazepines (such as diazepam, flurazepam, oxazepam, cloazepine, triazolam, alprazolam, esazolam, midazolam, etc.), barbiturates, carbamazepine, phenytoin, magnesium sulfate, chloral hydrate, etc..
• Pain relief and other drugs: Nonsteroidal anti-inflammatory drugs (aspirin is permitted for the prevention of cardiovascular events, provided it is used steadily for at least 30 days prior to randomization, Daily dose ≤100mg/ day), opioid agonists/antagonists, central alpha-adrenergic agonists (e.g. Clonidine, dexmedetomidine), anticonvulsants (e.g. Carbamazepine, pregabalin, gabapentin), antidepressants (e.g. Tricyclic, selective 5-HT reuptake inhibitors).

4. Others:

1. Subjects had a history of substance abuse, drug use, and/or alcohol abuse within the 1 year prior to randomization, with alcohol abuse defined as drinking an average of more than 2 units of alcohol per day (1 unit =360mL beer or 45mL liquor with 40% alcohol or 150 ml wine); Or consume alcoholic food or drink within 24 hours before receiving the study drug.

2. Subjects consumed excessive amounts of tea, coffee, grapefruit/grapefruit juice, grapefruit juice, caffeinated beverages (averaging more than 8 cups per day, 200 mL per cup) in the 14 days prior to randomization.

3. Female subjects who are pregnant or breastfeeding.

4. Subjects who have planned to have children within 30 days prior to the screening period and have planned to have children within six months from the date of signing the informed consent to the last use of the investigational drug and are unwilling or unable to use effective contraception.

5. Subjects who have participated in other clinical trials as subjects, and/or previously received investigational drug or device in this clinical trial within the 3 months prior to randomization.

6. Subjects who have any other factors deemed unsuitable for participation in this trial by the investigator.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Jiangsu HengRui Medicine Co., Ltd.

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Zhongshan Hospital Affiliated to Fudan University

Shanghai, Shanghai Municipality, China

Countries

China

Central Contacts

HaiBo Huang

Role: CONTACT

haibo.huang@hengrui.com

+0518-82342973

Facility Contacts

Changhong Miu

Role: primary

Other Identifiers

BULI-201

Identifier Type: -

Identifier Source: org_study_id