Elucidating How Physical Activity and Sleep Relate to Optimal Cognitive Ageing

NCT ID: NCT05455229

Last Updated: 2025-02-13

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 260 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2021-07-22
• Study Completion Date: 2024-03-31

Brief Summary

Increased longevity is one of the greatest success stories in public health. However, ageing is accompanied by cognitive decline which affects people's daily functioning and, if it develops to dementia, their ability to live independently. By 2050, the number of people who develop dementia will triple to 152 million. The aim of this project is to precisely examine how physical activity (PA) and sleep, both modifiable lifestyle factors, are related to cognitive function and which role they can play in optimal cognitive ageing. To do so, a longitudinal study will be conducted, with objective measures of PA, sleep and cognition in midlife and older adults. This project will meet the current need for longitudinal studies with objective PA and sleep data, as well as provide, for the first time, in-depth information on associations of type of PA (aerobic vs muscle strengthening), characteristics of sleep (quality vs quantity) with specific cognitive domains (executive function and memory). Furthermore, although PA and sleep are related, the behavioural dynamics of combinations of PA and sleep on cognition has never been studied before. To fill this gap, these relationships will be examined with an innovative statistical approach, looking at data across a 24-hour period. The resulting deeper understanding of the precise relationship between PA, sleep and cognitive function will contribute to the development of preventive interventions for maintaining cognitive health at older age.

Conditions

Cognitive Aging

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• Community dwelling, healthy adults aged 55 and above

Exclusion Criteria

1. has a neurodegenerative disease such as Parkinson's, Alzheimer's, MS…; or

2. has a psychiatric illness such as bipolar disorder, OCD…; or

3. has had a serious brain injury in the past year or before that is still affecting them; or

4. has had a brain haemorrhage; or

5. is currently experiencing a depressive episode; or

6. has a history of addiction or excessive alcohol abuse; or

7. uses a sleeping device (for sleep apnoea); or

8. has chronic insomnia (diagnosed insomnia); or

9. is severely limited in performing daily activities (up and down stairs, walk ...)

10. has a first-degree dementia within the family

11. scores a 23 or lower on the Montreal Cognitive Assessment

• Minimum Eligible Age: 55 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University Ghent

OTHER

Sponsor Role: collaborator

Research Foundation Flanders

OTHER

Sponsor Role: collaborator

KU Leuven

OTHER

Sponsor Role: lead

Responsible Party

Pieter-Jan Marent

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

KU Leuven

Leuven, Vlaams-Brabant, Belgium

Countries

Belgium

Other Identifiers

PASOCA_2021

Identifier Type: -

Identifier Source: org_study_id