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Acute Effects of Sitting and Physical Activity on Brain Health

NCT ID: NCT04137211

Last Updated: 2022-12-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

13 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-05-13

Study Completion Date

2020-03-13

Brief Summary

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The specific aim of this study is to understand how a working day composed of prolonged sitting, sitting regularly interrupted by light aerobic exercise or resistance exercise affects an important mechanism underpinning healthy brain functions, namely cerebral blood flow. It is primarily focused on investigating these effects in ecologically valid conditions, i.e. activity patterns that closely resemble a typical day at the office.

Detailed Description

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The study will be a controlled crossover experimental trial with three conditions involving 13 adult participants aged between 40 and 60 years. Each participant will complete each of the three experimental conditions, separated by a washout period of minimum four days. As well, physical activity behaviours and sleep the day/night before the test day will be measured. The first visit will be a familiarization session. On the second, third, and fourth visits, participants will undergo three different standardized 3-hour interventions in a randomized order. Before and immediately after the three-hour interventions, blood pressure, augmentation index, and cerebral hemodynamic response of the prefrontal cortex during standardized cognitive tasks (1,2, and 3-back tests) will be measured. Additionally, saliva samples will be collected the morning of the test day and before and after the interventions, blood glucose will be assessed continuously during the trial, and fitness will be measured at the familiarization visit.

Conditions

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Healthy Adults

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Prolonged sitting with social break

Group Type EXPERIMENTAL

Prolonged sitting with social break

Intervention Type BEHAVIORAL

Participants are required to sit for three hours (reading is permitted), with a toilet break in between. Every thirty minutes participants will have a short social break. Test day begins at 7:30 with pretest measures, followed by the intervention at about 9:00, which will end around 12:00, with subsequent posttest measures.

Prolonged sitting with walk break

Group Type EXPERIMENTAL

Prolonged sitting with walk break

Intervention Type BEHAVIORAL

Participants are required to sit for three hours (reading is permitted), with a toilet break in between. Every thirty minutes participants will have a physical activity break, where they will perform a brisk walk for about three minutes on a treadmill at a predetermined speed and grade based on the fitness test performed during the familiarization session. Test day begins at 7:30 with pretest measures, followed by the intervention at about 9:00, which will end around 12:00, with subsequent posttest measures.

Prolonged sitting with simple resistance activities

Group Type EXPERIMENTAL

Prolonged sitting with simple resistance activities

Intervention Type BEHAVIORAL

Participants are required to sit for three hours (reading is permitted), with a toilet break in between. Every thirty minutes participants will have a physical activity break, where they will perform simple resistance activities following a video for about three minutes. Test day begins at 7:30 with pretest measures, followed by the intervention at about 9:00, which will end around 12:00, with subsequent posttest measures.

Interventions

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Prolonged sitting with social break

Participants are required to sit for three hours (reading is permitted), with a toilet break in between. Every thirty minutes participants will have a short social break. Test day begins at 7:30 with pretest measures, followed by the intervention at about 9:00, which will end around 12:00, with subsequent posttest measures.

Intervention Type BEHAVIORAL

Prolonged sitting with walk break

Participants are required to sit for three hours (reading is permitted), with a toilet break in between. Every thirty minutes participants will have a physical activity break, where they will perform a brisk walk for about three minutes on a treadmill at a predetermined speed and grade based on the fitness test performed during the familiarization session. Test day begins at 7:30 with pretest measures, followed by the intervention at about 9:00, which will end around 12:00, with subsequent posttest measures.

Intervention Type BEHAVIORAL

Prolonged sitting with simple resistance activities

Participants are required to sit for three hours (reading is permitted), with a toilet break in between. Every thirty minutes participants will have a physical activity break, where they will perform simple resistance activities following a video for about three minutes. Test day begins at 7:30 with pretest measures, followed by the intervention at about 9:00, which will end around 12:00, with subsequent posttest measures.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

\- Has a BMI under 35kg/m2

Exclusion Criteria

* Has diabetes, epilepsy, or circulatory conditions
* Has experienced heart failure, stroke, or myocardial infarction
* Takes treatment for high blood pressure, sleep disorders, depression, or psychosis
Minimum Eligible Age

40 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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The Knowledge Foundation

UNKNOWN

Sponsor Role collaborator

ICA-gruppen

UNKNOWN

Sponsor Role collaborator

Intrum AB

UNKNOWN

Sponsor Role collaborator

SATS

UNKNOWN

Sponsor Role collaborator

Monark Exercise

UNKNOWN

Sponsor Role collaborator

Itrim

UNKNOWN

Sponsor Role collaborator

The Swedish School of Sport and Health Sciences

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Maria Ekblom, PhD

Role: PRINCIPAL_INVESTIGATOR

The Swedish School of Sport and Health Sciences (GIH)

Locations

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The Swedish School of Sport and Health Sciences (GIH)

Stockholm, , Sweden

Site Status

Countries

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Sweden

References

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Heiland EG, Tarassova O, Fernstrom M, English C, Ekblom O, Ekblom MM. Frequent, Short Physical Activity Breaks Reduce Prefrontal Cortex Activation but Preserve Working Memory in Middle-Aged Adults: ABBaH Study. Front Hum Neurosci. 2021 Sep 16;15:719509. doi: 10.3389/fnhum.2021.719509. eCollection 2021.

Reference Type DERIVED
PMID: 34602995 (View on PubMed)

Other Identifiers

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Dnr:2019-00998

Identifier Type: -

Identifier Source: org_study_id