Evaluation of V/Q Mismatch as Predictor of Pulmonary Postoperative Complications in Patients Undergoing Major Surgery
NCT ID: NCT05454917
Last Updated: 2022-07-12
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
101 participants
OBSERVATIONAL
2019-01-01
2022-05-31
Brief Summary
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Detailed Description
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PPC are classically considered associated to the occurrence of intraoperative atelectasis, and therefore to the development of a certain amount of shunt, but this concept have been recently questioned.
Recent studies showed indeed that, despite age is one of the main determinants of PPCs, increasing age is not associated to the increase of intraoperative shunt. Shunt therefore may not be the main determinant of PPC.
In this trial the investigators will evaluate if other causes of intraoperative VQ mismatch (e.g. low V/Q, high V/Q, dead space) may predict PPC in a population of patients undergoing major surgery.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Patients undergoing surgery
Mechanical measures, VQ mismatch evaluation
Measure of ventilation/perfusion (V/Q) mismatch using Beacon ALPE (Automatic Lung Paramether Estimator)
Evaluation of intraoperative V/Q mismatch using the Beacon ALPE during anesthesia.
Interventions
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Measure of ventilation/perfusion (V/Q) mismatch using Beacon ALPE (Automatic Lung Paramether Estimator)
Evaluation of intraoperative V/Q mismatch using the Beacon ALPE during anesthesia.
Eligibility Criteria
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Inclusion Criteria
* Major elective surgery with general anesthesia
* Intraoperative cannulation of the radial artery for invasive pressure monitoring
Exclusion Criteria
* Refuse to participate
* Emergency surgery
18 Years
90 Years
ALL
No
Sponsors
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Aalborg University
OTHER
Università degli Studi di Ferrara
OTHER
Responsible Party
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Savino Spadaro
Principal Investigator
Principal Investigators
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Savino Spadaro, MD, PhD
Role: STUDY_DIRECTOR
Università degli Studi di Ferrara
Gaetano Scaramuzzo, MD
Role: PRINCIPAL_INVESTIGATOR
Università degli Studi di Ferrara
Locations
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Azienda Ospedaliero Universitaria Sant'Anna
Ferrara, , Italy
Countries
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References
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Hedenstierna G, Tokics L, Scaramuzzo G, Rothen HU, Edmark L, Ohrvik J. Oxygenation Impairment during Anesthesia: Influence of Age and Body Weight. Anesthesiology. 2019 Jul;131(1):46-57. doi: 10.1097/ALN.0000000000002693.
Miskovic A, Lumb AB. Postoperative pulmonary complications. Br J Anaesth. 2017 Mar 1;118(3):317-334. doi: 10.1093/bja/aex002.
Spadaro S, Grasso S, Karbing DS, Santoro G, Cavallesco G, Maniscalco P, Murgolo F, Di Mussi R, Ragazzi R, Rees SE, Volta CA, Fogagnolo A. Physiological effects of two driving pressure-based methods to set positive end-expiratory pressure during one lung ventilation. J Clin Monit Comput. 2021 Oct;35(5):1149-1157. doi: 10.1007/s10877-020-00582-z. Epub 2020 Aug 20.
Jammer I, Wickboldt N, Sander M, Smith A, Schultz MJ, Pelosi P, Leva B, Rhodes A, Hoeft A, Walder B, Chew MS, Pearse RM; European Society of Anaesthesiology (ESA) and the European Society of Intensive Care Medicine (ESICM); European Society of Anaesthesiology; European Society of Intensive Care Medicine. Standards for definitions and use of outcome measures for clinical effectiveness research in perioperative medicine: European Perioperative Clinical Outcome (EPCO) definitions: a statement from the ESA-ESICM joint taskforce on perioperative outcome measures. Eur J Anaesthesiol. 2015 Feb;32(2):88-105. doi: 10.1097/EJA.0000000000000118.
Other Identifiers
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VQppc
Identifier Type: -
Identifier Source: org_study_id
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