Optimizing Breathing and Blood Flow in Patients Treated With VA ECMO

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ENROLLING_BY_INVITATION

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2026-01-27

Study Completion Date

2027-02-28

Brief Summary

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The aim of this study is to characterize ventilation/perfusion (V/Q) matching in adult patients receiving peripheral VA ECMO support while on mechanical ventilation, and to evaluate the impact of PEEP titration guided by Electrical Impedance Tomography (EIT) and esophageal pressure measurements on lung mechanics and V/Q optimization.

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Detailed Description

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The investigators hypothesize that an individualized PEEP titration guided by esophageal pressure measurements and Electrical Impedance Tomography can reduce lung overdistention, enhance lung recruitment, and improve V/Q matching by optimizing regional ventilation and perfusion also in VA ECMO.

Our objectives are:

1. To describe V/Q matching in patients undergoing mechanical ventilation during peripheral VA ECMO support.
2. To explore the impact of PEEP titration based on esophageal pressure and EIT in terms of lung mechanics and V/Q matching.

Conditions

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VA-ECMO

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Lung physiology assessment

Measurement of lung perfusion (via EIT) and transpulmonary pressure (via esophageal manometry) during decremental PEEP trial

Group Type OTHER

Physiology measurements

Intervention Type OTHER

Measurement of lung perfusion (via EIT) and transpulmonary pressure (via esophageal manometry) during decremental PEEP trial

Interventions

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Physiology measurements

Measurement of lung perfusion (via EIT) and transpulmonary pressure (via esophageal manometry) during decremental PEEP trial

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Adults (≥18 years) undergoing mechanical ventilation during peripheral VA ECMO support for cardiogenic shock, cardiac arrest, or refractory heart failure.
* On ECMO support for at least 6 hours
* Swan-Ganz catheter required as standard clinical care
* Clinically stable in the estimation of the study investigator

Exclusion Criteria

* Contraindications to EIT (e.g., presence of pacemaker or IMPELLA device for electrical interference)
* Patients without pulmonary flow (non-pulsatile pulmonary prSessure)
* Patients with known pulmonary embolism
* Imminent withdrawal of life support

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No