Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ACTIVE_NOT_RECRUITING
40 participants
OBSERVATIONAL
2015-01-15
2027-03-31
Brief Summary
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To investigate the ability of NIRS to detect vulnerable plaque characterized by the presence of OCT-defined TCFA To study the influence of gene polymorphisms (in genes playing role in vessel dilatation) on the progression of coronary atherosclerosis and clinical outcomes
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Detailed Description
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The second part of the trial is to investigate the ability of NIRS to detect vulnerable plaque characterized by the presence of OCT-defined TCFA.
A further target is to study the influence of gene polymorphisms (in genes playing a role in vessel dilatation) on the progression of coronary atherosclerosis and clinical outcomes. Patient DNA will be isolated from peripheral blood leucocytes, and polymorphisms in genes for Hemoxygenase-1 and endothelial Nitric Oxide Synthase will be analysed.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Interventions
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OCT, NIRS
Eligibility Criteria
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Inclusion Criteria
* Presence of at least one non-culprit coronary lesion (not indicated for revascularisation)
Exclusion Criteria
* Circulatory instability
* Renal insufficiency (creatinine level \>200umol/l)
* Pregnant or of childbirth age and not using reliable contraception
* Life expectancy of less than one year
18 Years
ALL
No
Sponsors
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Ministry of Health, Czech Republic
OTHER_GOV
Na Homolce Hospital
OTHER
Responsible Party
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Karel Kopriva
M.D
Locations
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Na Homolce Hospital
Prague, , Czechia
Countries
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Other Identifiers
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140504
Identifier Type: -
Identifier Source: org_study_id
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