Non-invasive and Invasive Plaque Characterisation

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-06-30

Study Completion Date

2013-05-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The accuracy of coronary plaque characterization with Multi-slice computed tomography as compared to intravascular ultrasound and optical coherence tomography will be investigated in patients presenting with acute coronary syndrome without ST-elevation.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Role of Intracoronary Imaging in Plaque Identification

NCT03953040

Coronary Artery Disease

WITHDRAWN

Identification Of High-risk Coronary Plaques By Multimodal Intravascular Imaging

NCT06681155

Coronary Arterial Disease (CAD) Acute Coronary Syndromes

NOT_YET_RECRUITING

Prediction of Atherosclerotic Plaque Progression

NCT05424705

Coronary Artery Disease

ACTIVE_NOT_RECRUITING

Intracoronary Imaging With NIRS-IVUS to Characterize Arterial Plaques

NCT01694368

Coronary Artery Disease

COMPLETED

Study of Coronary Plaque Rupture in Heart Attack Following Surgery Using Optical Coherence Tomography (OCT)

NCT01555177

Peri-operative Myocardial Infarction Non-ST Elevation Myocardial Infarction

UNKNOWN

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Non ST Elevation Myocardial Infarction

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Single arm

There is only one arm in this study. All patients undergo MSCT, IVUS and OCT.

Group Type OTHER

Imaging

Intervention Type DEVICE

All patients undergo non-invasive (MSCT) and invasive (IVUS, OCT) imaging

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Imaging

All patients undergo non-invasive (MSCT) and invasive (IVUS, OCT) imaging

Intervention Type DEVICE

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

OCT: C7-XR™ OCT Intravascular Imaging System, St.Jude Medical IVUS: Galaxy 2 IVUS Imaging System, Boston Scientific MSCT: Dual-source CT scanner Somatom Definition, Siemens Healhtcare

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Chest pain suggestive for myocardial ischemia for at least 30 minutes; - Electrocardiogram (ECG) with ST-segment shifts (ST-segment depression \>1 mm in at least two contiguous leads or transient ST-segment elevation \> 1mm with duration of \< 30 min in at least two contiguous leads) and/or T-wave changes (T-wave inversion \> 1.5 mm in at least three contiguous leads); - Positive hs Troponin T \> 14 ng/L or positive Troponin T \<0.01 µg/L - Clinical indication for invasive coronary angiography followed by PCI of the ischemia-related target lesion; - Informed consent.

Exclusion Criteria

* Persistent ST-elevation of \>1 mm in 2 or more leads; - Need for emergency invasive coronary angiography and percutaneous coronary intervention (PCI); - Need for emergency coronary artery bypass grafting; - Presence of cardiogenic shock; - Estimated glomerular filtration rate (eGFR) \< 50 ml/min; - Known allergy to iodine contrast agents; - Cardiac rhythms other than sinus rhythm; - Inability to lay supine; - Inability tot sustain a breath-hold for 15 seconds; - Inability to provide informed consent.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No