Placental Pathology and Inflammatory Factor Analysis of OAPS

NCT ID: NCT05378516

Last Updated: 2022-05-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

40 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-01-01

Study Completion Date

2023-12-31

Brief Summary

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This investigation is on placental pathological changes and inflammatory factors associated with obstetric antiphospholipid syndrome.

Detailed Description

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1\. To clarify the correlation between antiphospholipid antibody, ACC1 expression level, Treg cell and placental pathological changes associated with antiphospholipid syndrome. 2. Reveal that antiphospholipid antibodies affect Treg cell differentiation through the key enzyme of lipid metabolism ACC1.

Conditions

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Antiphospholipid Syndrome in Pregnancy

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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obstetric antiphospholipid syndrome

obstetric antiphospholipid syndrome 20 cases and normal pregnant women 20 cases

no intervention

Intervention Type OTHER

no intervention

Interventions

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no intervention

no intervention

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. pregnant women with antiphospholipid syndrome (diagnosed by experts with clinical evidence) and healthy pregnant women without antiphospholipid syndrome as a control group
2. consent to join this study and finish the informed consents

Exclusion Criteria

pregnant women with other autoimmune diseases
Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Peking University People's Hospital

OTHER

Sponsor Role lead

Responsible Party

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Yang Jingjing

Deputy chief physician

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jingjing Yang, doctor

Role: PRINCIPAL_INVESTIGATOR

Peking University People's Hospital

Locations

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PekingUPH

Beijing, , China

Site Status RECRUITING

Countries

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China

Central Contacts

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Jingjing Yang, deputy chief physician, doctor

Role: CONTACT

0086-13810625484

Xinyang Ma, resident, bachelor

Role: CONTACT

0086-18801152801

Facility Contacts

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Jingjing Yang, doctor

Role: primary

008613810625484

Xinyang Ma, bachelor

Role: backup

008618801152801

Other Identifiers

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yjjbear2022

Identifier Type: -

Identifier Source: org_study_id

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