VR for Improving Attention and Working Memory

NCT ID: NCT05369897

Last Updated: 2022-07-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-04-30

Study Completion Date

2023-06-30

Brief Summary

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The main objective of the study is to investigate the effects of using a set of Virtual Reality (VR)-based Digital Therapeutics (DTx) apps to improve the cognitive abilities of healthy (high-functioning) seniors. For the purposes of the study, high-functioning seniors are defined as being over the age of 65 years, while maintaining their functional independence with regards to activities of daily living, including the ability to go on a long walk and the ability to interact with common modern technology (e.g. using a smartphone to send a message).

The study focuses on improving the quality of life of older healthy people by facilitating cognitive training through VR. Healthy people aged 65-85 will be eligible for the project. If the participants meet the inclusion criteria, they will be invited to participate in the study and be provided with detailed information about the research project. Based on sample size calculations, up to two hundred (200) older adults are intended to be included in the project. The participants will use specially designed VR systems and activities aimed at improving their cognitive abilities.

Detailed Description

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The participants that meet inclusion criteria will be randomly assigned to the experimental group or the control group. The participants in the experimental group will receive a cognitive intervention focused on attention and working memory through virtual reality handsets. The intervention will be delivered at home and monitored by the research team via wifi. The participants will be required to perform the cognitive training at least 3 times a week for 12 weeks (36 training sessions). The participants in the control group will see high definition images through VR handsets without cognitive training.

The CNS-Vital Signs, a computerized neuropsychological battery, will be used to assess primary outcomes (Working Memory and Complex Attention), and will be administered to the participants before the intervention and after 36 training sessions. Differences in performance on primary and secondary outcomes will be analyzed with a Linear Mixed Model Analysis of Variance for longitudinal outcomes. Measures of anxiety and well-being will also be registered.

Conditions

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Virtual Reality

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Outcome Assessors
The participants will be randomly assigned to either the experimental or the control group, and will be blind to the group assignment.

The data gathered before and after the intervention will be sent to an external statistical analyst blinded to group assignment.

Study Groups

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VR training

VR training for at least 10 minutes at least three days per week, resulting in a total of at least 36 sessions (at least \~12 hours of training in total) for each participant, spread across three months. Each session will focus on cognitive training.

Group Type EXPERIMENTAL

VR training

Intervention Type DEVICE

The intervention group will receive cognitive training through VR headsets three times a week for 12 weeks. The intervention will be delivered in a virtual setting using images and music. The participants will be allowed to select the type of music and virtual environment during the intervention. The intervention will include four modules targeting attention and working memory through immersive VR.

VR activity

VR activity for at least 10 minutes at least three days per week, resulting in a total of at least 36 sessions (at least \~12 hours of training in total) for each participant, spread across three months, with 360º images and videos but without the interactive cognitive training.

Group Type SHAM_COMPARATOR

VR activity

Intervention Type DEVICE

High-quality 360º images and videos from natural environments, such as a relaxing mountain environment. The participants in the control group will not receive cognitive training.

Interventions

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VR training

The intervention group will receive cognitive training through VR headsets three times a week for 12 weeks. The intervention will be delivered in a virtual setting using images and music. The participants will be allowed to select the type of music and virtual environment during the intervention. The intervention will include four modules targeting attention and working memory through immersive VR.

Intervention Type DEVICE

VR activity

High-quality 360º images and videos from natural environments, such as a relaxing mountain environment. The participants in the control group will not receive cognitive training.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Healthy or in a stable medical condition
* Undisturbed locomotion
* Do not require care or help from others in their everyday functioning
* Are able to go on long walks unassisted
* Are able to use common modern technology unassisted (e.g. using a smartphone to send a message)

Exclusion Criteria

* Presence of neuropsychiatric disorders, including mild cognitive impairment (MCI) - Montreal Cognitive Assessment (MoCA) score \<26 points
* Abuse or addiction to alcohol, drugs and tranquilizers
* Blurred vision that cannot be corrected with lenses or glasses that fit under the VR headset
* Auditory pathologies causing a significant decrease in hearing unaided
* High sensitivity to motion sickness
* Proneness to migraines
* Subject epileptic
* Subject vulnerable
* Subject obese or frail, as assessed based on their Body Mass Index (BMI)
* Subject considered by the study investigator to be an unsuitable candidate to participate in the study, due to other relevant reasons
Minimum Eligible Age

65 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Center for Research and Development, Poland

OTHER

Sponsor Role collaborator

Senopi AG

UNKNOWN

Sponsor Role collaborator

Medical University of Lodz

OTHER

Sponsor Role lead

Responsible Party

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Jakub Kazmierski

Assoc. Prof. MD, PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jakub M Kaźmierski, PhD

Role: PRINCIPAL_INVESTIGATOR

Medical University of Lodz, Poland

Locations

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Department of Old Age Psychiatry and Psychotic Disorders Medical University of Lodz

Lodz, , Poland

Site Status RECRUITING

Countries

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Poland

Central Contacts

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Jakub M Kaźmierski, PhD

Role: CONTACT

426757232 ext. 0048

Ewa Ł Szczepocka, PhD

Role: CONTACT

426757346 ext. 0048

Facility Contacts

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Jakub Kaźmierski, PhD

Role: primary

0048426757232

References

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Szczepocka E, Mokros L, Kazmierski J, Nowakowska K, Lucka A, Antoszczyk A, Oltra-Cucarella J, Werzowa W, Hellevik MM, Skouras S, Bagger K. The Effectiveness of Virtual Reality-Based Training on Cognitive, Social, and Physical Functioning in High-Functioning Older Adults (CoSoPhy FX): 2-Arm, Parallel-Group Randomized Controlled Trial. JMIR Res Protoc. 2024 Jun 5;13:e53261. doi: 10.2196/53261.

Reference Type DERIVED
PMID: 38837194 (View on PubMed)

Szczepocka E, Mokros L, Kazmierski J, Nowakowska K, Lucka A, Antoszczyk A, Oltra-Cucarella J, Werzowa W, Hellevik M, Skouras S, Bagger K. Virtual reality-based training may improve visual memory and some aspects of sustained attention among healthy older adults - preliminary results of a randomized controlled study. BMC Psychiatry. 2024 May 8;24(1):347. doi: 10.1186/s12888-024-05811-2.

Reference Type DERIVED
PMID: 38720251 (View on PubMed)

Other Identifiers

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RNN/222/21/KE

Identifier Type: -

Identifier Source: org_study_id

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