High Frequency Percussive Ventilation in COVID-19 Patients

NCT ID: NCT05358184

Last Updated: 2022-05-03

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 15 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-05-15
• Study Completion Date: 2022-06-30

Brief Summary

High frequency percussive ventilation (HFPV) is used in patients with underlying pulmonary atelectasis, excessive airway secretions, and respiratory failure. HFPV is a non-continuous form of high-frequency ventilation delivered by a pneumatic device that provides small bursts of sub-physiological tidal breaths at a frequency of 60-600 cycles/minute superimposed on a patient's breathing cycle. The high-frequency breaths create shear forces causing dislodgement of the airway secretions. Furthermore, the HFPV breath cycle has an asymmetrical flow pattern characterized by larger expiratory flow rates, which may propel the airway secretions towards the central airway. In addition, the applied positive pressure recruits the lung units, resulting in a more homogeneous distribution of ventilation and improved gas exchange. In acute care and critical care settings, HFPV intervention is used in a range of patients, from spontaneously breathing patients to those receiving invasive mechanical ventilation where HFPV breaths can be superimposed on a patient's breathing cycle or superimposed on breaths delivered by a mechanical ventilator. The most common indications for HFPV use are reported as removal of excessive bronchial secretions, improving gas exchange, and recruitment of atelectatic lung segments. This study aims to assess the lung physiological response to HFPV in terms of aeration and ventilation distribution in patients with acute respiratory failure due to SARS-CoV-2 infection and requiring high flow oxygen therapy through nasal cannula

Conditions

COVID-19; Acute Respiratory Failure

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: OTHER
• Blinding Strategy: NONE

Study Groups

High frequency percussive ventilation

High Frequency Percussive Ventilation will be applied for 10 minutes at an oscillation frequency of 10 Hz, superimposed to oxygen therapy at high flow through nasal cannula

Group Type: EXPERIMENTAL

High frequency Percussive ventilation

Intervention Type: DEVICE

High Frequency Percussive Ventilation will be applied for 10 minutes at an oscillation frequency of 10 Hz

Interventions

High frequency Percussive ventilation

High Frequency Percussive Ventilation will be applied for 10 minutes at an oscillation frequency of 10 Hz

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• acute respiratory failure with a nasal swab positive for SARS-CoV-2
• need for high-flow oxygen through nasal cannula

Exclusion Criteria

• life threatening cardiac arrythmia
• pneumothorax
• acute spinal injury
• chest trauma
• hemodynamic instability
• chest or abdominal surgery in the previous 7 days
• pregnancy
• enrollment in other study protocols

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University Magna Graecia

OTHER

Sponsor Role: lead

Responsible Party

Federico Longhini

Director of the Intensive Care and Anesthesia Department

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Federico Longhini, MD

Role: PRINCIPAL_INVESTIGATOR

Magna Graecia University

Central Contacts

Federico Longhini, MD

Role: CONTACT

longhini.federico@gmail.com

+393475395967

Other Identifiers

Percussionaire COVID

Identifier Type: -

Identifier Source: org_study_id