Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
60 participants
INTERVENTIONAL
2022-12-28
2026-12-31
Brief Summary
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Detailed Description
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Other than fulfilling the definition for sepsis-3, patients need to be equipped with an arterial catheter to be eligible for inclusion. After informed consent (from next of kin when applicable) baseline blood samples are drawn from existing catheter and the subject is given a bolus dose of 20umol/kg 13C-labeled lactate in 20 ml isotonic saline. After this a total of 14 blood samples รก 2 ml is drawn in the following 120 minutes. All blood samples are centrifuged and stored in -800 C until analysis. After all subjects have been included sampled are thawed and analyzed for content of endogenous and labeled lactate. Through analysis between their relationship the lactate production and consumption can be quantified.
Conditions
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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All patients
All patients receive the same intervention/sampling protocol
Isotopically labeled lactate
A bolus dose of isotopically labeled lactate is given and blood samples from existing catheters are drawn
Interventions
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Isotopically labeled lactate
A bolus dose of isotopically labeled lactate is given and blood samples from existing catheters are drawn
Eligibility Criteria
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Inclusion Criteria
* Age \>17 years
* Arterial catheter
* Lactate \> 2 mmol at any time point prior to inclusion
Exclusion Criteria
* Degenerative muscle disease
* Terminal liver failure
18 Years
ALL
No
Sponsors
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Region Stockholm
OTHER_GOV
European Society of Intensive Care Medicine
OTHER
The Scandinavian Society of Anaesthesiology and Intensive Care Medicine (SSAI)
UNKNOWN
Karolinska University Hospital
OTHER
Responsible Party
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Jonathan Grip
Principal Investigator, PhD
Locations
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Karolinska University Hospital
Stockholm, Stockholm County, Sweden
Countries
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Central Contacts
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Facility Contacts
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Christian Ahlstedt, MD
Role: backup
References
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Grip J, Falkenstrom T, Promsin P, Wernerman J, Norberg A, Rooyackers O. Lactate kinetics in ICU patients using a bolus of 13C-labeled lactate. Crit Care. 2020 Feb 10;24(1):46. doi: 10.1186/s13054-020-2753-6.
Other Identifiers
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K 2022-4066
Identifier Type: -
Identifier Source: org_study_id
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