Protocol-driven Hemodynamic Support for Patients With Septic Shock

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

70 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-09-30

Study Completion Date

2011-01-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This research is being done to see if a protocol (a set of orders that determine how much and how quickly a drug/fluid is given) for fluid and drugs used to increase blood pressure (vasopressors) will work better then general clinical practices to improve outcomes in patients with septic shock.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Vasopressin Hemodynamic Response as a Septic Shock Subphenotype Indicator

NCT06426407

Shock, Septic

RECRUITING

Efficacy of Targeted Abdominal Perfusion Pressure in Septic Shock

NCT05358912

Septic Shock Septicemia Intraabdominal Hypertension +1 more

COMPLETED PHASE4

Effects of Targets of Blood Pressure on Cerebral Hemodynamics in Septic Shock

NCT05833607

Septic Shock Cerebral Autoregulation

UNKNOWN

Preemptive Resuscitation for Eradication of Septic Shock

NCT01449721

Sepsis Severe Sepsis

COMPLETED NA

Hemodynamic and Perfusion Response to Drotrecogin Alfa (Activated) in Patients With Septic Shock

NCT00279214

Sepsis Septic Shock

COMPLETED PHASE4

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Septic shock is low blood pressure caused by an infection. Sepsis is the most common cause of death in non-cardiac intensive care units, and septic shock is the most severe form of sepsis. Treatment for septic shock includes giving antibiotics, intravenous fluids, and medications to raise the blood pressure (vasopressors).

We would like to see if a protocol-driven management strategy for septic shock can shorten time on vasopressors and limit the number of side effects. We have constructed a protocol that will allow the nurse at the bedside, in conjunction with the physician's orders, to adjust the amount of fluids and medications that raise the blood pressure (vasopressors).

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Shock, Septic Severe Sepsis Sepsis

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Fluid and Vasopressor Protocol

A Physician Ordered, Nurse Administered Fluid and Vasopressor Protocol

Intervention Type PROCEDURE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* ACCP/SCCM sepsis criteria
* Need for institution of vasopressors after adequate volume resuscitation

Exclusion Criteria

* Age\< 18
* On vasopressors for \> 24 hours prior to ICU admission
* Other cause for shock ( cardiac tamponade, massive pulmonary embolus, cardiogenic shock)
* Physicians and family not committed to aggressive medical therapy ( a patient will not be excluded if he/she would receive all care except for attempts at resuscitation from cardiac arrest)

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No