Metabolic Cluster Analysis in Septic Shock Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

120 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-05-01

Study Completion Date

2026-10-31

Brief Summary

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Observational study including septic shock patients within 24 hours of ICU admission, monitored with a cardiac output estimation system, with ongoing resuscitation. Hemodynamic and metabolic parameters before and after a fluid challenge (FC) will be measured.

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Detailed Description

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Conditions

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Septic Shock

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Septic shock

Septic shock patients within the first 24 hours of ICU admission, and selected by the attending physician for performing a fluid challenge (FC) due to suspected tissue hypoperfusion.

Fluid challenge

Intervention Type OTHER

Rapid infusion (\< 15 minutes) of a fluid bolus of crystalloids (200 to 500cc)

Interventions

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Fluid challenge

Rapid infusion (\< 15 minutes) of a fluid bolus of crystalloids (200 to 500cc)

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

\- Septic shock patients within the first 24 hours of ICU admission, and selected by the attending physician for performing a fluid challenge (FC) due to suspected tissue hypoperfusion (elevated lactate and/or ScvO2 \< 70%).

Exclusion Criteria

* Age under 18 years old
* Uncontrolled hemodynamic instability, defined as the need for significant changes in vasopressor support (\> 10% from baseline dose) within the 15-minute period prior to, and/or during the administration of fluids.
* Patients receiving continuous renal replacement therapies, since the CO values obtained from the thermodilution techniques might be potentially affected.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No