Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
60 participants
OBSERVATIONAL
2022-04-01
2022-12-31
Brief Summary
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Detailed Description
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In clinical practice, liver function can be evaluated by gadoxate enhanced MRI by measuring signal intensity. Most often, simple visual assessment is performed, but quantitative measurements are also done. Theoretically, liver function should also be possible to quantify by using delta radiomics, ie by subtracting MR imaging features obtained in the earlier phase from the latter phase.
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Control Group
Healthy volunteers undergoing MRI exam, ICG test and blood biochemical tests
No interventions assigned to this group
Child-Pugh A Group
Composed of patients with liver function of Child-Pugh A grade undergoing MRI exam, ICG test and blood biochemical tests
No interventions assigned to this group
Child-Pugh B Group
Composed of patients with liver function of Child-Pugh B grade undergoing MRI exam,ICG test and blood biochemical tests
No interventions assigned to this group
Child-Pugh C Group
Composed of patients with liver function of Child-Pugh C grade undergoing MRI exam
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Patients with chronic liver disease and different degrees of liver damage (Child-Pugh A, B and C) and healthy controls.
* No history of liver-related surgery (except for cholecystectomy).
* No cardiopulmonary diseases or other diseases which may impair liver function.
* Agree to participate in the study and provide written informed consent.
Exclusion Criteria
* Liver tumors or metastasis or other extraheptic tumor.
* Splenectomy or other cases where the spleen is absent.
* Chronic kidney disease, renal damage.
* Allergy to contrast agents or other conditions that cannot undergo Gd-EOB-DTPA enhanced MRI exam.
18 Years
70 Years
ALL
Yes
Sponsors
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Zhujiang Hospital
OTHER
Responsible Party
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Yingfang Fan
Professor
Locations
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The First Department of Hepatobiliary Surgery, Zhujiang Hospital
Guangzhou, Guangdong, China
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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2021-KY-105-02
Identifier Type: -
Identifier Source: org_study_id
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