Ventilation Modes Effect on Intracranial Pressure During Laparoscopic Colectomy by Optic Nerve Sheath Diameter

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

78 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-04-30

Study Completion Date

2023-04-30

Brief Summary

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Patients who undergo laparoscopic surgery often experience increased intracranial pressure (ICP). In laparoscopic colectomy surgery, the duration always exceeds 2h with more liability to changes in arterial blood gases, hemodynamics, also the patient is in Trendelenburg position about 30° head down, Trendelenburg position is believed to create changes in hemodynamics, respiratory mechanics, metabolic response, and ICP as it affects vital organs especially if steep positioning. Various modes of mechanical ventilation have been experimented to achieve good intraoperative oxygenation which may cause changes in arterial blood gas values and hemodynamic parameters that might lead to changes in the ICP. In this study we will measure ONSD, basal, intraoperative, and in the PACU to evaluate the effect of different ventilation modes (both VCV mode and PCV-VG mode) on intracranial pressure.

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Detailed Description

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The aim of the current study is to compare the effect of volume control ventilation (VCV) versus pressure control ventilation-volume guaranteed (PCV-VG) as modes of mechanical ventilation on ICP by US guided ONSD measurement during laparoscopic colectomy,

Conditions

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Laparoscopic Colectomy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Volume control ventilation group

Patients' lungs will be ventilated with volume control ventilation mode

Group Type PLACEBO_COMPARATOR

Volume control ventilation group

Intervention Type DEVICE

Volume control ventilation mode

Pressure control ventilation-volume guaranteed group

patients' lungs will be ventilated with Pressure control ventilation-volume guaranteed mode

Group Type ACTIVE_COMPARATOR

Pressure control ventilation-volume guaranteed group

Intervention Type DEVICE

Pressure control ventilation-volume guaranteed mode

Interventions

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Volume control ventilation group

Volume control ventilation mode

Intervention Type DEVICE

Pressure control ventilation-volume guaranteed group

Pressure control ventilation-volume guaranteed mode

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Body mass index less than 30
* American Society of Anesthesiologist physical class I -III.

Exclusion Criteria

* Patient refusal
* operative time \< 2 hour (h)
* Patients with preexisting eye disease.
* History of eye surgery
* Optic nerve disease.
* Causes of elevated ICP.

Minimum Eligible Age

21 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No