REVIVe: Frailty, Rehabilitation, and Outcomes in Critically Ill Adult and Pediatric Survivors of COVID-19 or ARI
NCT ID: NCT05246098
Last Updated: 2024-11-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
900 participants
OBSERVATIONAL
2022-08-24
2025-10-01
Brief Summary
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Objectives: The main goal of this research study is to see if patients with frailty have a lower chance of surviving COVID-19 or acute respiratory infection critical illness and more health problems after survival than patients without frailty. The investigators will also study the types of rehabilitation received by patients with COVID-19 or acute respiratory infection.
Methods: The investigators will include adults and children with COVID-19 or acute respiratory infection who are admitted to the ICUs that participate in the study. The investigators will gather data about each patient, including before and during their illness.
Outcomes: The investigators will collect level of frailty, function, and types of therapy, or rehabilitation received by patients. In adults, the investigators are most interested in learning if frailty influences mortality, or death. In children, the investigators are most interested in whether children with COVID-19 or acute respiratory infection critical illness are more likely to develop frailty. The investigators will also study post-hospital discharge location in survivors (e.g., home, rehabilitation).
Relevance: The COVID-19 pandemic is a global public health crisis. It is critical to understand how COVID-19 and other acute respiratory infection critical illness affects groups of people who are at higher risk, and the impact on outcomes that are important to patients, like functioning and QOL. The results will help policy makers plan post-hospital services for survivors, help healthcare workers understand the importance of rehabilitation practice for patients with COVID-19 or acute respiratory infection, and help researchers develop treatments to improve QOL after COVID-19 or acute respiratory infection.
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Detailed Description
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Conditions
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Study Design
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COHORT
OTHER
Study Groups
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Adults
Adult survivors of COVID-19 or acute respiratory infection admitted to participating ICUs. Adults are defined as greater than or equal to, 18 years old. We will include adults with a confirmed diagnosis of COVID-19 or those with suspected or proven acute respiratory infection with onset within 14 days of ICU admission and requiring invasive mechanical ventilation, non-invasive ventilation, or high-flow oxygen therapy.
No interventions assigned to this group
Pediatrics
Pediatric survivors of COVID-19, MIS-C, or acute respiratory infection admitted to participating pediatric intensive care units (PICUs). The investigators define children as less than 18 years old. We will include pediatric patients with COVID-19, those with multi-system inflammatory syndrome in children (MIS-C), and those with suspected or proven acute respiratory infection with onset within 14 days of ICU admission and requiring invasive mechanical ventilation, non-invasive ventilation, or high-flow oxygen therapy.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
ALL
No
Sponsors
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Canadian Institutes of Health Research (CIHR)
OTHER_GOV
Canadian Critical Care Trials Group
OTHER
McMaster University
OTHER
Responsible Party
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Principal Investigators
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Michelle E Kho, PT, PhD
Role: PRINCIPAL_INVESTIGATOR
McMaster University
Locations
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Alberta Children's Hospital
Calgary, Alberta, Canada
University of Alberta
Edmonton, Alberta, Canada
Sturgeon Community Hopsital
St. Albert, Alberta, Canada
Royal Columbian Hospital
New Westminster, British Columbia, Canada
Children's Hospital of Winnipeg
Winnipeg, Manitoba, Canada
QEII Health Sciences Centre
Halifax, Nova Scotia, Canada
Izaak Walton Killam Hospital for Children
Halifax, Nova Scotia, Canada
Brantford General Hospital
Brantford, Ontario, Canada
Hamilton General Hospital
Hamilton, Ontario, Canada
St. Joseph's Healthcare Intensive Care Unit
Hamilton, Ontario, Canada
McMaster Children's Hospital
Hamilton, Ontario, Canada
Juravinski Hospital
Hamilton, Ontario, Canada
Kingston Health Sciences Centre
Kingston, Ontario, Canada
London Health Sciences Centre
London, Ontario, Canada
Children's Hospital of Eastern Ontario
Ottawa, Ontario, Canada
The Ottawa Hospital
Ottawa, Ontario, Canada
Niagara Health System
St. Catharines, Ontario, Canada
Sunnybrook Hospital
Toronto, Ontario, Canada
St. Michael's Hospital
Toronto, Ontario, Canada
The Hospital for Sick Children
Toronto, Ontario, Canada
Hôpital Hôtel-Dieu de Lévis
Lévis, Quebec, Canada
Centre hospitalier de l'Université de Montréal
Montreal, Quebec, Canada
The Centre hospitalier universitaire Sainte-Justine
Montreal, Quebec, Canada
Montreal Children's Hospital
Montreal, Quebec, Canada
Hôpital du Sacré-Cœur de Montréal
Montreal, Quebec, Canada
Institut Universitaire de Cardiologie et de Pneumologie de Québec
Québec, Quebec, Canada
Hôpital Fleurimont - Sherbrooke
Sherbrooke, Quebec, Canada
Saskatchewan Health Authority
Regina, Saskatchewan, Canada
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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REVIVe
Identifier Type: -
Identifier Source: org_study_id
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