Resident Memory T Cells in Vitiligo

NCT ID: NCT05223738

Last Updated: 2022-02-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

29 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-12-31

Study Completion Date

2022-02-01

Brief Summary

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This study aims to detect the presence and diversity of Tissue resident memory T cell populations in early and late cases of generalized non-segmental Vitiligo.

Detailed Description

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* Written informed consent obtained from every participant.
* Detailed history taking including onset, course, duration of the disease, aggravating factors and received medications
* VASI score assessed in every patient.
* Patients photographed, divided into two groups early \& late cases and 3 mm punch biopsies will be taken from perilesional and non lesional skin.
* Biopsies processed and stained for CD8 \& CD69 in cases of early group, \& late group and controls by immunofluorescence.

Conditions

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Vitiligo

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* \- Patients with Generalized non-segmental Vitiligo ( lesions in more than one anatomical site ).
* Both genders.
* Early group: onset less than or equal 6 months.
* Late group: onset more than 6 months

Exclusion Criteria

* Localized or Segmental Vitiligo.
* Age \< 14 years.
* Pregnant females
* Patient who received treatment of any type within the last 3 months for the late group.
* Patients with other skin diseases or immunosuppression
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Kasr El Aini Hospital

OTHER

Sponsor Role lead

Responsible Party

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Rana F Hilal, MD

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Hilal

Role: PRINCIPAL_INVESTIGATOR

Kasr El Ainy University Hospital, Faculty of medicine, Cairo University

Locations

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Kasr El Ainy University hospital

Cairo, , Egypt

Site Status

Countries

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Egypt

Other Identifiers

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TRMvit

Identifier Type: -

Identifier Source: org_study_id

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