Sensory Symptoms in Active Vitiligo

NCT ID: NCT05390164

Last Updated: 2022-05-25

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 90 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2022-05-25
• Study Completion Date: 2022-08-15

Brief Summary

This work aims to assess sensory symptoms in early active vitiligo patients (segmental, non-segmental, or mixed) and to measure 3 neuropeptides expression in their lesional skin [neuropeptide Y(NPY), calcitonin gene-related peptide (CGRP), and nerve growth factors (NGF)] to correlate neuropeptide levels, sensory symptoms, and functions, with criteria of disease activity and perceived stress scale.

Detailed Description

Study Design: Case-control study Population: 45 patients with active vitiligo and 45 patients with stable vitiligo

Inclusion criteria:

Age: 18 years old and older Sex: both sexes

Exclusion criteria:

Other hypopigmented diseases such as pityriasis alba, tinea versicolor, lichen sclerosis, post-inflammatory hyperpigmentation, and leprosy as excluded by lack of accentuation by wood's light examination. - Cases who received treatment (systemic or topical) in the last 3 months before sampling. - Neurological or other diseases that cause itching. - Medical history of DM, HTN, or other systemic diseases, history of associated autoimmune diseases.

Assessment will be carried as follows: • History of itching or other abnormal neurological sensations as paresthesia and numbness. Aggravating factors (e.g. dryness, hot environment, sun exposure, ..etc), alleviating factors of itching Type of vitiligo (segmental, unilateral, vulgaris). • Assessment of activity by assessing: koebner's phenomenon, confetti depigmentation, trihypochrome areas, poorly defined borders, inflammatory signs (e.g eye inflammation and hearing loss), and leukotrichia. • Assessment of sensory symptoms and signs (fine touch, crude touch, pain, and sweating by starch iodine test) in active vitiliginous patches. • Clinical assessment: the vitiligo area score index (VASI), vitiligo extent scores (VES), vitiligo disease activity score (VIDA) (Feily, 2014) will be assessed in every participant and demographic data

Conditions

Totest Sensory Symptoms in Active Vitiligo

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

Active vitiligo

skin biopsy

Intervention Type: DIAGNOSTIC_TEST

skin biopsy to be analyzed by ELISA

Stable vitiligo

skin biopsy

Intervention Type: DIAGNOSTIC_TEST

skin biopsy to be analyzed by ELISA

Interventions

skin biopsy

skin biopsy to be analyzed by ELISA

Intervention Type: DIAGNOSTIC_TEST

Eligibility Criteria

Inclusion Criteria

• Active and stable vitiligo

Exclusion Criteria

• Diabetic or other associated disease

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Cairo University

OTHER

Sponsor Role: lead

Responsible Party

Hagar El Sayed

Dr

Responsibility Role: PRINCIPAL_INVESTIGATOR

References

El Sayed H, El Wakeel H, Nour Z, Mohyeeldeen R, Hafez V. Sensory Symptoms as an Early Manifestation of Active Vitiligo: A Case-Control Clinical and Molecular Study. Pigment Cell Melanoma Res. 2025 Jan;38(1):e13223. doi: 10.1111/pcmr.13223.

Reference Type: DERIVED

PMID: 39869070 (View on PubMed)

Other Identifiers

Pruritis in vitiligo

Identifier Type: -

Identifier Source: org_study_id