Assessment of Hypoxia Inducible Factor and Autophagy Related Genes in Patients With Non-Segmental Vitiligo
NCT ID: NCT06410898
Last Updated: 2024-05-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
RECRUITING
NA
30 participants
INTERVENTIONAL
2024-04-25
2024-07-25
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
1. The presence of Hypoxia Inducible Factor in vitiligo patient
2. Defect of Autophagy Related Genes in vitiligo patient
3. The cross relation between Autophagy Related Genes and Hypoxia Inducible Factor in the pathogenesis of vitiligo among Egyptian patients in Sohag Governorate
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Histochemical Study of Vitiligo in Sohag University Hospital Patients
NCT05869942
Evaluation of Pyroptosis-related Indicators in the Pathogenesis of Vitiligo:Across-sectional Comparative Study
NCT06261086
Leucotrichia in Vitiligo
NCT03402633
Vitiligo, New Treatment and Serum s100B
NCT06768840
Evaluation of Serum and Tissue Cathepsin L in Non-segmental Vitiligo Patients
NCT06261073
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
skin biopsy from vitiligo lesion in vitiligo patient
punch biopsy 5mm from vitiligo patch in vitiligo patient
Punch Biopsy 5mm
Disinfect the skin, inject local anesthesia ,insert the punch and extract the biopsy
skin biopsy from normal skin in vitiligo patient
punch biopsy 5mm from normal skin patch in vitiligo patient
Punch Biopsy 5mm
Disinfect the skin, inject local anesthesia ,insert the punch and extract the biopsy
skin biopsy from normal skin in normal person
punch biopsy 5mm from normal skin patch in normal person
Punch Biopsy 5mm
Disinfect the skin, inject local anesthesia ,insert the punch and extract the biopsy
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Punch Biopsy 5mm
Disinfect the skin, inject local anesthesia ,insert the punch and extract the biopsy
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* With non segmental vitiligo
* A group of participants will be included as a control group
Exclusion Criteria
* Patient with chronic inflammatory skin disorders
* patient on anti-oxidant or anti-inflammatory drugs
* patient on topical or systemic treatment for vitiligo in last 4 weeks
* patients with other autoimmune diseases
* patients with diabetes mellitus
18 Years
75 Years
ALL
Yes
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Sohag University
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Rania Hassan Metwaly
Resident Dermatologist in Akhmim hospital
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Sohag University hospitals
Sohag, , Egypt
Countries
Review the countries where the study has at least one active or historical site.
Central Contacts
Reach out to these primary contacts for questions about participation or study logistics.
Reham E El-Sharkawy, Professor
Role: CONTACT
Facility Contacts
Find local site contact details for specific facilities participating in the trial.
References
Explore related publications, articles, or registry entries linked to this study.
Agarwal S, Ganesh S. Perinuclear mitochondrial clustering, increased ROS levels, and HIF1 are required for the activation of HSF1 by heat stress. J Cell Sci. 2020 Jul 9;133(13):jcs245589. doi: 10.1242/jcs.245589.
Artika IM, Dewi YP, Nainggolan IM, Siregar JE, Antonjaya U. Real-Time Polymerase Chain Reaction: Current Techniques, Applications, and Role in COVID-19 Diagnosis. Genes (Basel). 2022 Dec 16;13(12):2387. doi: 10.3390/genes13122387.
Bastonini E, Kovacs D, Raffa S, Delle Macchie M, Pacifico A, Iacovelli P, Torrisi MR, Picardo M. A protective role for autophagy in vitiligo. Cell Death Dis. 2021 Mar 25;12(4):318. doi: 10.1038/s41419-021-03592-0.
Ezzedine K, Lim HW, Suzuki T, Katayama I, Hamzavi I, Lan CC, Goh BK, Anbar T, Silva de Castro C, Lee AY, Parsad D, van Geel N, Le Poole IC, Oiso N, Benzekri L, Spritz R, Gauthier Y, Hann SK, Picardo M, Taieb A; Vitiligo Global Issue Consensus Conference Panelists. Revised classification/nomenclature of vitiligo and related issues: the Vitiligo Global Issues Consensus Conference. Pigment Cell Melanoma Res. 2012 May;25(3):E1-13. doi: 10.1111/j.1755-148X.2012.00997.x.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
Soh-Med-24-04-014MS
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.