Analysis of Inflammation in the Vitiligo and Other Inflammatory Skin Diseases: Psoriasis, Atopic Dermatitis and Alopecia Areata

NCT ID: NCT03976622

Last Updated: 2019-06-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

450 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-06-03

Study Completion Date

2023-06-03

Brief Summary

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It is a study of translational research with mechanistically objectives and including biological samples of patients with chronic inflammatory disorders

Detailed Description

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This study was a single-center prospective study to collect blood and skin tissue at the time of consultation with a patient with non-segmental vitiligo, psoriasis, atopic dermatitis or alopecia areata, in order to better understand and compare blood and skin immune response in chronic inflammatory skin disorders: psoriasis, alopecia areata, atopic dermatitis and vitiligo.

Conditions

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Vitiligo Psoriasis Alopecia Areata Atopic Dermatitis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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vitiligo

Patients aged 18 to 75 years with non-segmental vitiligo;

Blood samples

Intervention Type BIOLOGICAL

Blood samples: serum and PBMC

Skin biopsies

Intervention Type BIOLOGICAL

These superficial skin biopsies under local anesthesia in skin areas with the exception of the face and folds.

psoriasis

Patients aged 18 to 75 years with plaque psoriasis;

Blood samples

Intervention Type BIOLOGICAL

Blood samples: serum and PBMC

Skin biopsies

Intervention Type BIOLOGICAL

These superficial skin biopsies under local anesthesia in skin areas with the exception of the face and folds.

atopic dermatitis

Patients aged 18 to 75 years with atopic dermatitis;

Blood samples

Intervention Type BIOLOGICAL

Blood samples: serum and PBMC

Skin biopsies

Intervention Type BIOLOGICAL

These superficial skin biopsies under local anesthesia in skin areas with the exception of the face and folds.

alopecia areata

Patients aged 18 to 75 years with alopecia areata sclerosis;

Blood samples

Intervention Type BIOLOGICAL

Blood samples: serum and PBMC

Skin biopsies

Intervention Type BIOLOGICAL

These superficial skin biopsies under local anesthesia in skin areas with the exception of the face and folds.

Interventions

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Blood samples

Blood samples: serum and PBMC

Intervention Type BIOLOGICAL

Skin biopsies

These superficial skin biopsies under local anesthesia in skin areas with the exception of the face and folds.

Intervention Type BIOLOGICAL

Other Intervention Names

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Blood samples: serum and PBMC

Eligibility Criteria

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Inclusion Criteria

* Patients aged 18 to 75 years;
* Patients with non-segmental vitiligo;
* Patients with plaque psoriasis;
* Patients with atopic dermatitis;
* Patients with alopecia areata sclerosis;
* written consent, free, informed and signed by the patient and the investigator (before any examination required by the study);
* Subject affiliated or beneficiary of a social security system.

Exclusion Criteria

* Patients with segmental vitiligo
* Patients under local treatment (topical corticosteroid-Calcineurin inhibitor) for less than two weeks.
* Patients on therapy, systemic treatments: acitretin, methotrexate, cyclosporine, Apremilast, infliximab, adalimumab, etanercept, ustekinumab, secukinumab, ixekizumab, dupilumab) for less than 4 weeks.
* Pregnant or breastfeeding women
* Patient (e) under guardianship
* Patient (e) Non-affiliated (e) a social protection
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Bordeaux

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Julien SENESCHAL, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Bordeaux

Locations

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Service de Dermatologie - Hôpital Saint-André

Bordeaux, , France

Site Status

Countries

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France

Central Contacts

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Julien SENESCHAL, MD,PhD

Role: CONTACT

+335 56 79 49 63

Sitraka ANDRIAMIASY

Role: CONTACT

+335.56.82.06.55

Other Identifiers

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CHUBX 2017/55

Identifier Type: -

Identifier Source: org_study_id

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