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The Mechanism of Melanocyte Self-Assembly on Biomaterials and the Functional Analysis

NCT ID: NCT00509314

Last Updated: 2007-07-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

400 participants

Study Classification

OBSERVATIONAL

Study Start Date

2006-05-31

Study Completion Date

2016-12-31

Brief Summary

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The aim of this study is to survey melanocytes in the ability of self-assembly on biomaterials and functional analysis in vitro. Also, this study may provide a better way for treatment of vitiligo after understanding the functional aspects of melanocytes.

Detailed Description

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Vitiligo is a chronic disease that causes loss of melanocyte and pigment of the skin. Traditional treatments for vitiligo including topical corticosteroids and phototherapy lead to limited clinical effects. Autologous melanocyte transplantation is another way to treat vitiligo. However, the effect is largely affected by whether cultivated melanocytes are successfully uptaken by vitiliginous skin. The aim of this study is to survey the self-assembly on biomaterials and functional analysis. In the long run, this study may provide a better way for treatment of vitiligo.

Conditions

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Melanocyte Vitiligo

Study Design

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Observational Model Type

NATURAL_HISTORY

Study Time Perspective

OTHER

Interventions

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melanocyte self-assembly and functional analysis

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Patients receiving cosmetic removal of moles
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Science and Technology Council, Taiwan

OTHER_GOV

Sponsor Role collaborator

National Health Research Institutes, Taiwan

OTHER

Sponsor Role collaborator

National Taiwan University Hospital

OTHER

Sponsor Role lead

Principal Investigators

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Sung-Jan Lin, MD PhD

Role: PRINCIPAL_INVESTIGATOR

National Taiwan University Hospital

Locations

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National Taiwan University Hospital

Taipei, , Taiwan

Site Status RECRUITING

Countries

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Taiwan

Central Contacts

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Sung-Jan Lin, MD PhD

Role: CONTACT

Phone: +886-2-23123456

Email: [email protected]

Facility Contacts

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Sung-Jan Lin, MD PhD

Role: primary

References

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Lin SJ, Jee SH, Hsaio WC, Lee SJ, Young TH. Formation of melanocyte spheroids on the chitosan-coated surface. Biomaterials. 2005 Apr;26(12):1413-22. doi: 10.1016/j.biomaterials.2004.05.002.

Reference Type BACKGROUND
PMID: 15482829 (View on PubMed)

Lin SJ, Jee SH, Hsiao WC, Yu HS, Tsai TF, Chen JS, Hsu CJ, Young TH. Enhanced cell survival of melanocyte spheroids in serum starvation condition. Biomaterials. 2006 Mar;27(8):1462-9. doi: 10.1016/j.biomaterials.2005.08.031. Epub 2005 Sep 19.

Reference Type BACKGROUND
PMID: 16171860 (View on PubMed)

Other Identifiers

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9561703036

Identifier Type: -

Identifier Source: org_study_id